DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6227 and ddx42

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	XP_002935570.1	Gene:	ddx42 / 100135374	XenbaseID:	XB-GENE-972670	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	877	Identity:	294/877 - (33%)
Similarity:	437/877 - (49%)	Gaps:	137/877 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LDSGKKDAEPDSPP---SKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKK 306
            :.:|||: ||..|.   |.|.|...:|....  |...|        ||.|:|     ...|:..:
Frog    21 ISTGKKE-EPKLPQASHSAFQSSAAKFGSST--SNQLP--------SFYKIG-----SKRANFDE 69

  Fly   307 EPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPED 371
            |....|.:                         |:.....:.|::.|::.| ...:...:|:.:.
Frog    70 ENAYFDDE-------------------------EEDSSNVDLPYIPAENSP-TRQQLHSKADSDS 108

  Fly   372 EIDPLDAYMQEVNN----EMRRVNNFVNPPAKSQGV-----------VILTGVAKKKTTTLKKGE 421
            |.|||:|:|.||.:    :||::.........::|:           .....:|:..|.    |.
Frog   109 EEDPLEAFMAEVEDQAAKDMRKLEERDKEKKNARGIRDDIEEEDDQEAYFRYMAENPTA----GL 169

  Fly   422 VIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAA 486
            |.|:..|:|||.|:.  ..|..|...:.    ..|..|||:.:.|.||.||||.|..|:|..|..
Frog   170 VPEEEEDNLEYDSDG--NPIAPTTKRII----DPLPPIDHTEIEYTPFEKNFYEEHEEITSQTPQ 228

  Fly   487 DVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLI 551
            .:.:.|..| .::|.|...|:...::|..|..::.|..:|:..:.:|||||||.:|..:||||:|
Frog   229 QITELRHKL-NLRVSGAAPPRLCSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMI 292

  Fly   552 GIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVC 616
            ||||||||||.|||.|:..||:||..::.|||.||:|:.||||||.||..:.::|.|:..||.|.
Frog   293 GIAKTGSGKTAAFIWPILVHIMDQKELQPGDGPIAVIVCPTRELCQQIHSECKRFGKAYNLRSVA 357

  Fly   617 VYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQV 681
            ||||..:.||...|:.||||:||||||:||.:   ..:.|||:||||:|.||||||||||||.||
Frog   358 VYGGGSMWEQAKALQEGAEIVVCTPGRLIDHV---KKKATNLQRVTYLVFDEADRMFDMGFEYQV 419

  Fly   682 MRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVIL-NDDAKFF 745
            ..|.::|||||||::|||||.:::|.|||.||..||.|:.|......:::.|.|.|| :...|:.
Frog   420 RSIANHVRPDRQTLLFSATFRKKIEKLARDILVDPIRVVQGDIGEANEDITQVVEILPSGPEKWT 484

  Fly   746 KLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRL 810
            .|...|..:...||:::||.|:.||:.|..:|.:..:|...|||.:||.:|:..|.|||...:.:
Frog   485 WLTRRLVEFTSTGSVLIFVTKKANAEELANNLRQDDHPLGLLHGDMDQSERNKVISDFKKKSIPV 549

  Fly   811 LIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRA 875
            |:||.|||||||:..:..|:||||....:.:.||.|||||||:||.|:|.:||:.|.:|||::|.
Frog   550 LVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAHTLLTPKDSNFAGDLVRN 614

  Fly   876 MD-----LSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKA 935
            ::     :|..|:...:|..|......:..:||.::.|||  |.|::               ::.
Frog   615 LEGANQYVSKELLDLAMQNSWFRKSRFKAGKGKKLNIGGG--GLGYR---------------ERP 662

  Fly   936 ALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAA-------AAAAAAAAAAVSGA 993
            .||...||  ..:..::....|........:.|..:|..||..:       ||:|:......|..
Frog   663 GLGAETSD--RGVGGNVMSNYEAFKPTGGAMGDRLSAMKAAFQSQYKNHFVAASASTQKTGTSSI 725

  Fly   994 NPALASAAAQAAAAAAA--ANIAIAAASAPAAAGGAPSV--AMGGALSSDKLELAKRLASKINSS 1054
            |....::|...::..:|  .::.:.|.:||      |.|  .|.|..||
Frog   726 NSGAWTSAGSLSSVPSAHPPSVKLPAEAAP------PPVHTTMLGFTSS---------------- 768

  Fly  1055 KNLDTKGSVVTVEPMIKGPHVTGAAATLLTAR 1086
               .|..|:.|..|.|.  :.:..||||..||
Frog   769 ---GTLSSIPTGYPNIS--NASYPAATLFGAR 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	202/490 (41%)
		DEADc	516..719	CDD:238167	115/202 (57%)
		HELICc	733..860	CDD:238034	54/127 (43%)
ddx42	XP_002935570.1	PTZ00110	196..650	CDD:240273	206/457 (45%)
ddx42	XP_002935570.1	PRK12678	733..>940	CDD:237171	22/90 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920