DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and pak1ip1

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001017054.2	Gene:	pak1ip1 / 549808	XenbaseID:	XB-GENE-492186	Length:	365	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	117/409 - (28%)
Similarity:	196/409 - (47%)	Gaps:	71/409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPEMEIIVGTYEEVLLGFKLIKSPTDGLTDSVKFELKQTFADSSHAGSITSVAVQWPWVASGGT 65
            |...||::||.||:||.|:::.:.....|:.:       .|...:|..|::.|||...:||:|..
Frog     1 MEEYMELVVGCYEQVLFGYRVHREGEQWLSSA-------DFTHHAHTASLSVVAVNNRFVATGSK 58

  Fly    66 DDRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSHLLSGSDDGHMIATRVGSWTKEGDWQKAHA 130
            |:.|.:|||:.:.:...:|.|.|.:..|:|..: :|||||::||.:.......|..:..: |||.
Frog    59 DETIQIYDMKKKVEHGALLHHNGTITCLQFYGN-THLLSGAEDGLICVWNTKKWECQQTF-KAHK 121

  Fly   131 GQAVTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYKTNLKNKATLGLQPGCLSWSKQGDHFTL 195
            || |..:|.|||.|||||:|.|:.|.|||||.||.|:..|:|..|.:      :.||..||.:.:
Frog   122 GQ-VLSLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKKNAHI------VQWSPSGDKYVV 179

  Fly   196 SGPLVLEIWGIENAHVMRRIEMPAKPICITWL-DGNECLTGLDNGNIAWISLKDED-----DTPP 254
            .....::::.:|.|.|:..|..|.:...:.:: |....:.|            ||:     ||..
Frog   180 VIHDKVDVYQLETAAVIGTINNPKRISSVQFITDALIAVAG------------DEEVIRLYDTAS 232

  Fly   255 TFIL----AHEARVKAIAYL----NELLATVSSAGEIKVWKIDMETRK-----LEEIASSFMDCR 306
            ...:    |||.|||.:...    ..::.:.||.|.:|:|.||.|..|     |.|:::|   .|
Frog   233 QKCVCEFKAHENRVKNLHVFELEETHIVVSSSSDGFVKMWGIDTEKVKTPPSLLCEVSTS---AR 294

  Fly   307 PTDLGL-----LDLRQFGNVQPVEQRIKVEEKPKAKVESDQSAKPAAPRGFVTIEYEQDKNLDAE 366
            .|.|.:     :|.::..|.......:|..::||.|:...::|                :|.:|.
Frog   295 LTCLSVWLPSAVDHKEEANRDVTASTVKDCDRPKKKMTQSKTA----------------ENKEAG 343

  Fly   367 KKKGKGKKNKIQAKKAQQK 385
            :.:...||.|::.|:.::|
Frog   344 ETQVIHKKRKLETKQKKKK 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	82/269 (30%)
		WD40	45..295	CDD:295369	85/268 (32%)
		WD40 repeat	51..85	CDD:293791	11/33 (33%)
		WD40 repeat	90..128	CDD:293791	10/37 (27%)
		WD40 repeat	135..170	CDD:293791	20/34 (59%)
		WD40 repeat	181..214	CDD:293791	7/32 (22%)
		WD40 repeat	264..286	CDD:293791	6/25 (24%)
pak1ip1	NP_001017054.2	WD40	<35..294	CDD:225201	88/282 (31%)
		WD40	39..272	CDD:238121	80/253 (32%)
		WD40 repeat	43..78	CDD:293791	11/34 (32%)
		WD40 repeat	84..119	CDD:293791	10/36 (28%)
		WD40 repeat	124..160	CDD:293791	21/35 (60%)
		WD40 repeat	168..200	CDD:293791	7/31 (23%)
		WD40 repeat	205..240	CDD:293791	6/46 (13%)
		WD40 repeat	248..288	CDD:293791	10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39574
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010