DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and wds

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	65/313 - (20%)
Similarity:	117/313 - (37%)	Gaps:	89/313 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GTYEEVLLGFK-------------LIKSPTDGLTDSVKFELK-----QTFADSSHAGSITSVAVQ 56
            |.:|:.:.|.|             |:.|.:|..|..| :||.     :|....|:.....:...|
  Fly   104 GKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKV-WELSTGKSLKTLKGHSNYVFCCNFNPQ 167

  Fly    57 WPWVASGGTDDRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSHLLSGSDDGHMIATRVGSWTK 121
            ...:.||..|:.:.::|:||.|..:.:.:|:..|:.:.|..|.|.::|.|.||   ..|:
  Fly   168 SNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG---LCRI----- 224

  Fly   122 EGDWQKAHAGQA-----------VTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYKTNLKNKA 175
               |..| :||.           |:.:...|:.|..|:...|..|..|:...|: ..||...:|.
  Fly   225 ---WDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK-CLKTYTGHKN 284

  Fly   176 TLGLQPGCL--SWSKQGDHFTLSG--PLVLEIWGIENAHVMRRIEMPAKPICITWLDGNECLTGL 236
                :..|:  ::|..|..:.:||  ..::.||.:::..|:::::.....:..|.....|
  Fly   285 ----EKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTE----- 340

  Fly   237 DNGNIAWISLKDEDDTPPTFILAHEARVKAIAYLNELLATVSSAGEIKVWKID 289
               ||...:..:.|.|                              ||:||.|
  Fly   341 ---NIIASAALENDKT------------------------------IKLWKSD 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	56/275 (20%)
		WD40	45..295	CDD:295369	53/260 (20%)
		WD40 repeat	51..85	CDD:293791	8/33 (24%)
		WD40 repeat	90..128	CDD:293791	10/37 (27%)
		WD40 repeat	135..170	CDD:293791	8/34 (24%)
		WD40 repeat	181..214	CDD:293791	8/36 (22%)
		WD40 repeat	264..286	CDD:293791	2/21 (10%)
wds	NP_001245503.1	WD40	64..358	CDD:238121	62/309 (20%)
		WD40 repeat	75..112	CDD:293791	2/7 (29%)
		WD40 repeat	118..154	CDD:293791	8/36 (22%)
		WD40 repeat	159..195	CDD:293791	8/35 (23%)
		WD40 repeat	202..237	CDD:293791	12/46 (26%)
		WD40 repeat	244..280	CDD:293791	10/36 (28%)
		WD40 repeat	288..325	CDD:293791	8/36 (22%)
		WD40 repeat	331..357	CDD:293791	8/63 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840