DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12608 and Poc1

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001261799.1	Gene:	Poc1 / 39502	FlyBaseID:	FBgn0036354	Length:	403	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	79/365 - (21%)
Similarity:	145/365 - (39%)	Gaps:	84/365 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GFKLIKSPTDGLTDSVKFELKQT-----FADSSHAGSITSVAVQWPW------VASGGTDDRIFV 71
            |.::..|.||...  :.:.|.|.     ||  ||:..:..||    |      |||.|.|..:.:
  Fly    30 GAQIATSSTDSTV--ILWNLNQAARCIRFA--SHSAPVNGVA----WSPKGNLVASAGHDRTVKI 86

  Fly    72 YDMRTRKQSQIILSHAGRVNTLKFTPDLSHLLSGSDDGH----MIATR--VGSWTKEGDWQKAHA 130
            ::.:.|..|...::|:..|.::.|......:|:.|||..    .:|.|  |.|:.::.:|
  Fly    87 WEPKLRGVSGEFVAHSKAVRSVDFDSTGHLMLTASDDKSAKIWRVARRQFVSSFAQQNNW----- 146

  Fly   131 GQAVTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYKTNLKNKATLGLQPGCLSWSKQGDH--- 192
               |......|:.||..:...|:.:..:::.:|. ..:|..:.:|.    |..|:|...|:.
  Fly   147 ---VRSAKFSPNGKLVATASDDKSVRIYDVDSGE-CVRTFTEERAA----PRQLAWHPWGNMLAV 203

  Fly   193 ---------FTLSGPLVLEIWGIENAHVMRRIEMPAKPICITWLDGNECLTGLDNGNIAWISLKD 248
                     |.:||..:|:::.:.:|.|......|:         |:..|:|.|:..|..:.|.
  Fly   204 ALGCNRIKIFDVSGSQLLQLYVVHSAPVNDVAFHPS---------GHFLLSGSDDRTIRILDLL- 258

  Fly   249 EDDTPPTFILAHEARVKAIAYL--NELLATVSSAGEIKVWKIDMETRKLEE------IASSFMD- 304
             :..|...:..|...|.|:|:.  .:..||..|..::.||:.::.|....:      :|||..:
  Fly   259 -EGRPIYTLTGHTDAVNAVAFSRDGDKFATGGSDRQLLVWQSNLHTYDASQFEAKSALASSSCES 322

  Fly   305 -------------CRPTDLGL-LDLRQFGNVQPVEQRIKV 330
                         .:..||.: :|.||....|..|:..:|
  Fly   323 SGVSSKQSEGSSTSKSNDLSIRIDPRQSLAYQLSEENFQV 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	63/286 (22%)
		WD40	45..295	CDD:295369	60/275 (22%)
		WD40 repeat	51..85	CDD:293791	10/39 (26%)
		WD40 repeat	90..128	CDD:293791	11/43 (26%)
		WD40 repeat	135..170	CDD:293791	5/34 (15%)
		WD40 repeat	181..214	CDD:293791	10/44 (23%)
		WD40 repeat	264..286	CDD:293791	6/23 (26%)
Poc1	NP_001261799.1	WD40	10..298	CDD:238121	66/299 (22%)
		WD40	14..388	CDD:225201	79/365 (22%)
		WD40 repeat	22..58	CDD:293791	8/31 (26%)
		WD40 repeat	63..99	CDD:293791	10/39 (26%)
		WD40 repeat	106..140	CDD:293791	8/33 (24%)
		WD40 repeat	147..183	CDD:293791	7/36 (19%)
		WD40 repeat	189..224	CDD:293791	8/34 (24%)
		WD40 repeat	231..254	CDD:293791	7/31 (23%)
		WD40 repeat	273..297	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930