DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and Pak1ip1

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001032433.1	Gene:	Pak1ip1 / 361232	RGDID:	1565353	Length:	382	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	127/466 - (27%)
Similarity:	200/466 - (42%)	Gaps:	112/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MEIIVGTYEEVLLGFKLIKSPTDGLTDSVKFELKQT------FADSSHAGSITSVAVQWPWVASG 63
            ||::.|:||:||.||.:.:.|       .|...::|      |...:|..|:::||....:|.:|
  Rat     1 MELVAGSYEQVLFGFTVHRGP-------AKSGHRETWTPVADFTHHAHTASLSAVAANNRYVVTG 58

  Fly    64 GTDDRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSHLLSGSDDGHMIATRVGSWTKEGDWQ-- 126
            ..|:.|.:|||:.:.:...::.|:|.|..|||... .||:||::||.:..     |..: .|:
  Rat    59 SKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGS-RHLISGAEDGLICV-----WDAK-KWECL 116

  Fly   127 ---KAHAGQAVTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYKTNLKNKATLGLQPGCLSWSK 188
               |||.|. ||.:|.|||.|||||:|.|:.|.|||||.||.|:..|:|..|.:      :.||.
  Rat   117 KSIKAHRGH-VTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHI------VEWSP 174

  Fly   189 QGDHFTLSGPLVLEIWGIENAHVMRRIEMPAKPICITWLDGNECLTGLDNGNIAWISLKDEDDTP 253
            .|:.:.:.....::::.::.|.|...:....:...||:|..:......|...:.:.   |.|
  Rat   175 NGEKYVVVVMNKVDVYHLDTASVSGTLTNGKRISAITFLSDSVLAVAGDEEVVRFF---DCD--- 233

  Fly   254 PTFIL-----AHEARVKAIAYL----NELLATVSSAGEIKVWKIDMETRKLEE-IASSFMDCRPT 308
             |.:.     |||.|||.:...    :.:|.|.|:.|.||:|.:..:.:.... :..:....|.|
  Rat   234 -TLVCLCEFKAHENRVKDMVSFEIPDHHVLVTASNDGFIKMWTLTQDKKAPPSLLCETNTGARLT 297

  Fly   309 DLGL-LDLRQFGNVQPVEQRIKVEEKPKAKVESDQSAKPAAPRGFVTIEYEQDKNLDAEKKKGKG 372
            .||: ||.             ..:|  ||::.......|..|:   |||.|
  Rat   298 CLGVWLDR-------------GTDE--KARLPPATEPCPDQPK---TIEKE-------------- 330

  Fly   373 KKNKIQAKKAQQKAEESSEESNSSEEKESDDFSDSDSDVSSDHGHRKRKPMKRKQQPTPASKGK- 436
                 .|.|.|::|...:.|                   .|||....::|.|| ..|.||.|.|
  Rat   331 -----SADKIQEEASAPNAE-------------------KSDHTGGSQQPTKR-NSPAPAKKRKM 370

  Fly   437 ----AKQQKKK 443
                .|::|||
  Rat   371 ANVSEKKRKKK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	82/275 (30%)
		WD40	45..295	CDD:295369	79/263 (30%)
		WD40 repeat	51..85	CDD:293791	9/33 (27%)
		WD40 repeat	90..128	CDD:293791	12/42 (29%)
		WD40 repeat	135..170	CDD:293791	21/34 (62%)
		WD40 repeat	181..214	CDD:293791	5/32 (16%)
		WD40 repeat	264..286	CDD:293791	8/25 (32%)
Pak1ip1	NP_001032433.1	WD40	<37..274	CDD:225201	78/257 (30%)
		WD40	41..274	CDD:295369	78/253 (31%)
		WD40 repeat	45..80	CDD:293791	9/34 (26%)
		WD40 repeat	86..121	CDD:293791	11/41 (27%)
		WD40 repeat	126..162	CDD:293791	22/35 (63%)
		WD40 repeat	207..242	CDD:293791	7/41 (17%)
		WD40 repeat	250..291	CDD:293791	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39574
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4554
OMA	1	1.010	-	-		QHG59992
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm44652
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.670