DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and pak1ip1

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_957239.2	Gene:	pak1ip1 / 336470	ZFINID:	ZDB-GENE-030131-8414	Length:	368	Species:	Danio rerio

Alignment Length:	397	Identity:	123/397 - (30%)
Similarity:	197/397 - (49%)	Gaps:	58/397 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPEMEIIVGTYEEVLLGFKLIKSPTDGLTDSVKFELKQTFADSSHAGSITSVAVQWPWVASGGT 65
            |...:|::.|.||:::.|:::  .|.|     .::.::.||...:|..|:.:|:....::|:|..
Zfish     8 MGDHIELVAGCYEQIVFGYRV--CPAD-----EEWTIEPTFTHHAHTASLNAVSSSNQFIATGSK 65

  Fly    66 DDRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSHLLSGSDDGHMIATRVGSW-TKEGDWQ--- 126
            |:.|.:|||..:.:...:|.|.|.::.|:|. ..||||||..||.:..     | ||:  |:
Zfish    66 DETIQLYDMCKKTEHGALLHHDGTISCLEFY-GTSHLLSGGQDGLICV-----WSTKK--WECLK 122

  Fly   127 --KAHAGQAVTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYKTNLKNKATLGLQPGCLSWSKQ 189
              :||.|| ||.:|.|||.|||||:|.|:.|.||||:.||.|:..|:|..|.:.|      ||..
Zfish   123 TIRAHKGQ-VTSLSVHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKQNAEIVL------WSPD 180

  Fly   190 GDHFTLSGPLVLEIWGIENAHVMRRIEMPAKPICITWLDGNECLTGLDNGNIAWISLKDEDDTPP 254
            ||.:.:.....::|:.:::|.::..|....:..|:.:|..:....|.|:.     |::..|.|..
Zfish   181 GDKYAVVVNDKVDIYTLDSATIIGTIAFTKRISCLKFLKNSLLAVGGDDE-----SVRIYDVTSQ 240

  Fly   255 TFIL---AHEARVKAI-AYLNE---LLATVSSAGEIKVWKIDMETRKLEEIASSFMDCRPTDLGL 312
            ..:.   |||.||||| :::.:   :|.|.|:.|.||:||::     ||.|.|      ||.||.
Zfish   241 KCVCEFKAHENRVKAIESFMKDDFCVLVTASNDGFIKLWKLN-----LESIES------PTLLGQ 294

  Fly   313 LD----LRQFGNVQPVEQRIKVEEKPKAKVESDQSAKPAAP--RGFVTIEYEQDKNLDAEKKKGK 371
            |:    |.......|.|.: :..|:|.....|:....|..|  ...|.|..|:....|.:..|.:
Zfish   295 LNTTARLTCLCVWMPGETK-ETAEQPAQATTSEDVLDPLVPVRSKRVRILGEEVIMEDEKGSKTQ 358

  Fly   372 GKKNKIQ 378
            |||.|.|
Zfish   359 GKKKKRQ 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	88/268 (33%)
		WD40	45..295	CDD:295369	86/262 (33%)
		WD40 repeat	51..85	CDD:293791	8/33 (24%)
		WD40 repeat	90..128	CDD:293791	14/43 (33%)
		WD40 repeat	135..170	CDD:293791	20/34 (59%)
		WD40 repeat	181..214	CDD:293791	6/32 (19%)
		WD40 repeat	264..286	CDD:293791	10/25 (40%)
pak1ip1	NP_957239.2	WD40	<36..288	CDD:225201	91/276 (33%)
		WD 1	45..82		10/36 (28%)
		WD40	46..280	CDD:238121	84/253 (33%)
		WD40 repeat	49..85	CDD:293791	9/35 (26%)
		WD 2	85..123		16/45 (36%)
		WD40 repeat	90..125	CDD:293791	14/42 (33%)
		WD 3	126..165		25/39 (64%)
		WD40 repeat	132..167	CDD:293791	20/34 (59%)
		WD 4	207..245		7/42 (17%)
		WD40 repeat	212..237	CDD:293791	5/29 (17%)
		WD 5	248..289		20/51 (39%)
		WD40 repeat	253..279	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39574
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4491
OMA	1	1.010	-	-		QHG59992
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm26090
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1339
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.700