DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and CG3436

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001285543.1	Gene:	CG3436 / 33180	FlyBaseID:	FBgn0031229	Length:	347	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	51/262 - (19%)
Similarity:	89/262 - (33%)	Gaps:	81/262 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 HAGSITSVAV--QWPWVASGGTDDRIFVYDMRTRKQSQIILS-HAGRVNTLKFTPDLSHLLSGSD 107
            |.|.|.:...  :...:.|.|.|.:|:::.:....::.:.:| |:|.|....||||.||:.:.|.
  Fly    54 HEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYEDCENVMAMSGHSGAVMEAHFTPDGSHIFTCST 118

  Fly   108 DGHM----IATRVGSWTKEGDWQKAHAGQAVTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYK 168
            |..:    |||        |..|:...|..                         |.||.
  Fly   119 DKTLAFWDIAT--------GQRQRRFKGHG-------------------------NFVNS----- 145

  Fly   169 TNLKNKATLGLQPGCLSWSKQGDHFTLSG--PLVLEIWGIENAHVMRRIEMPAKPICITWLD-GN 230
                           :..|::|.....||  ...::||.....|....:|.|.:...:.:.| |.
  Fly   146 ---------------VQGSRRGQQLLCSGSDDRTIKIWDARKKHAAHTLESPFQVTAVCFGDTGE 195

  Fly   231 ECLT-GLDNGNIAW--------ISLKDEDDTPPTFILAHEARVKAIAYLNELLATVSSAGEIKVW 286
            :.:: |:||....|        ..|:...||.....|:.|         .:.:.|.:....::||
  Fly   196 QVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPE---------GDFILTNAMDNTLRVW 251

  Fly   287 KI 288
            .:
  Fly   252 DV 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	51/262 (19%)
		WD40	45..295	CDD:295369	51/262 (19%)
		WD40 repeat	51..85	CDD:293791	4/35 (11%)
		WD40 repeat	90..128	CDD:293791	14/41 (34%)
		WD40 repeat	135..170	CDD:293791	3/34 (9%)
		WD40 repeat	181..214	CDD:293791	7/34 (21%)
		WD40 repeat	264..286	CDD:293791	1/21 (5%)
CG3436	NP_001285543.1	WD40	<19..346	CDD:225201	51/262 (19%)
		WD40	50..342	CDD:238121	51/262 (19%)
		WD40 repeat	58..96	CDD:293791	5/37 (14%)
		WD40 repeat	102..138	CDD:293791	13/43 (30%)
		WD40 repeat	143..180	CDD:293791	9/56 (16%)
		WD40 repeat	186..221	CDD:293791	6/34 (18%)
		WD40 repeat	227..267	CDD:293791	5/36 (14%)
		WD40 repeat	277..313	CDD:293791
		WD40 repeat	319..342	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930