DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and skb15

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_587918.1	Gene:	skb15 / 2538757	PomBaseID:	SPCC16C4.08c	Length:	341	Species:	Schizosaccharomyces pombe

Alignment Length:	441	Identity:	97/441 - (21%)
Similarity:	177/441 - (40%)	Gaps:	125/441 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MEIIVGTYEEVLLGFKLIKSPTDGLTDSVKFELKQTFADSSHAGSITSVAVQWPWVASGGTDDRI 69
            :..:||||..::.|..         .|..:.:.|..:...:|.|::|::||...::||..:|:.|
pombe     2 LRFVVGTYTHLIYGVD---------ADIERKKCKPLWLFEAHEGALTALAVDGIYLASTSSDETI 57

  Fly    70 FVYDMRTRKQSQII-----LSHAGRVNTLKFTPDLSHLLSGSDDGHMIATRVGSWTKEGDWQKAH 129
            .::|.....|...:     :::| .:..:.||.  :|||:..|:|     ::..|:| |.|...|
pombe    58 KIFDHTRNVQIADVSVPTDIANA-CIRDMCFTK--NHLLACHDNG-----QISMWSK-GSWLLVH 113

  Fly   130 -----AGQAVTHISCHPSSKLALSLGGDQVLNTWNLV---NGRVAYKTNLKNKATLGLQPGCLSW 186
                 :.:.:|.|:.|||.||||::|||..|..|:||   .|:|...:.:........:...:..
pombe   114 TLKSSSHKGITGIAVHPSEKLALTVGGDGKLRLWDLVRGKGGKVLPLSTIPESILFLNESSFVIM 178

  Fly   187 SKQG-DHFTLSGPLVLEIWGIENAHVMRRIEMPAKPICITWLDGNECLTGLDNGNIAWISLKDED 250
            |::| |.|.|.   :..::...:       :.....:|   |..::.:.|.|||.:..:
pombe   179 SRRGIDAFKLD---LTSLFSFSS-------KSQLNALC---LYQSKLIVGRDNGTVLVL------ 224

  Fly   251 DTPPTFIL----AHEARVKAIAYLNELLATVSSAGEIKVWKIDMETRKLEEIASSFMDCRPTDLG 311
            ||....||    ||:.|||::..:::.|.|.||.|.:.:|..|...
pombe   225 DTSDGKILHEFTAHKKRVKSVYPVDDYLITASSDGSVCIWDKDWNL------------------- 270

  Fly   312 LLDLRQFGNVQPVEQRIKVEEKPKAKVE--SDQSAKPAAPRGFVTIEYEQDKNLDAEKKKGKGKK 374
                       .:|..|....:....|.  :|.:::|              ||::.|..|
pombe   271 -----------VIEHNIPEGNRITCMVAMLADSNSEP--------------KNVEDEAAK----- 305

  Fly   375 NKIQAKKAQQKAEESSEESNSSEEKESDDFSDSDSDVSSDHGHRKRKPMKR 425
                    :|..:..:.|::|..|.||:.:|.|           |:.|:||
pombe   306 --------RQSLDSETSETSSESESESEYYSTS-----------KQPPVKR 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	69/273 (25%)
		WD40	45..295	CDD:295369	69/267 (26%)
		WD40 repeat	51..85	CDD:293791	9/38 (24%)
		WD40 repeat	90..128	CDD:293791	11/37 (30%)
		WD40 repeat	135..170	CDD:293791	18/37 (49%)
		WD40 repeat	181..214	CDD:293791	5/33 (15%)
		WD40 repeat	264..286	CDD:293791	7/21 (33%)
skb15	NP_587918.1	WD40	30..>280	CDD:225201	71/307 (23%)
		WD40	31..267	CDD:295369	68/263 (26%)
		WD40 repeat	37..79	CDD:293791	9/41 (22%)
		WD40 repeat	82..116	CDD:293791	12/41 (29%)
		WD40 repeat	124..195	CDD:293791	23/73 (32%)
		WD40 repeat	202..236	CDD:293791	10/42 (24%)
		WD40 repeat	242..275	CDD:293791	10/62 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I1759
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm47038
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	1	1.100	-	-	LDO	PTHR44675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1339
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850