DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and wdr-5.3

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001024299.1	Gene:	wdr-5.3 / 179489	WormBaseID:	WBGene00013862	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	74/374 - (19%)
Similarity:	119/374 - (31%)	Gaps:	147/374 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LIKSPTDGLTDSVKFELKQTFADSSHAGSITSVAVQW--PWVASGGTDDRIFVYDMRTRKQSQII 83
            :.|.|.:|     :|.|.:|.  |.|..|::.:...:  .::.:|..|.:|.|::.......|.:
Worm   194 ITKKPENG-----EFSLVKTI--SGHTKSVSVIKFSYCGKYLGTGSADKQIKVWNTVDMTYLQTL 251

  Fly    84 LSHAGRVNTLKFTPDLSHLLSGSDD----------GHMIATRVGSWTKEGDWQKAHAGQAVTHIS 138
            .||...:|...::.:...:.|.|||          |..:.|..|.               ..::.
Worm   252 ASHQLGINDFSWSSNSQFIASASDDTTVKIFDVISGACLRTMRGH---------------TNYVF 301

  Fly   139 C---HPSSKLALSLGGDQVLNTWNLVNGRVAYKTNLKNKATLGLQPGCLSWSKQGDHFTLSGPLV 200
            |   :|.|.|..|.|.|:.:..|:       :||        ||...|:
Worm   302 CCSFNPQSSLIASAGFDETVRVWD-------FKT--------GLCVKCI---------------- 335

  Fly   201 LEIWGIENAHVMRRIEMPAKPICITWL----DGNECLTGLDNGNI-AW--------ISLKDEDDT 252
                             ||....||.:    |||...|...:|.| .|        .:|.|.|..
Worm   336 -----------------PAHSDPITSISYNHDGNTMATSSYDGCIRVWDAASGSCLKTLVDTDHA 383

  Fly   253 PPTFI-------------------LAHEARVKAIAYLNE-------LLATV-----------SSA 280
            |.||:                   |....:.|.:.|.|.       |.|.:           |..
Worm   384 PVTFVCFSPNGKYLLSAQLDSSLKLWDPKKAKPLKYYNGHKNKKYCLFANMSVPLGKHIISGSED 448

  Fly   281 GEIKVWKIDMETRKLEEIASSF------MDCRPTDLGLLDLRQFGNVQP 323
            |.|.||.|  :|:::.:|....      .|..||    |::...|.::|
Worm   449 GRILVWSI--QTKQIVQILEGHTTPVLATDSHPT----LNIIASGGLEP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	62/320 (19%)
		WD40	45..295	CDD:295369	60/314 (19%)
		WD40 repeat	51..85	CDD:293791	5/35 (14%)
		WD40 repeat	90..128	CDD:293791	8/47 (17%)
		WD40 repeat	135..170	CDD:293791	9/37 (24%)
		WD40 repeat	181..214	CDD:293791	1/32 (3%)
		WD40 repeat	264..286	CDD:293791	8/39 (21%)
wdr-5.3	NP_001024299.1	WD40	<200..501	CDD:225201	72/368 (20%)
		WD40	205..499	CDD:238121	70/358 (20%)
		WD40 repeat	216..253	CDD:293791	5/36 (14%)
		WD40 repeat	259..295	CDD:293791	7/35 (20%)
		WD40 repeat	300..336	CDD:293791	13/83 (16%)
		WD40 repeat	343..378	CDD:293791	8/34 (24%)
		WD40 repeat	385..421	CDD:293791	5/35 (14%)
		WD40 repeat	429..466	CDD:293791	10/38 (26%)
		WD40 repeat	472..498	CDD:293791	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930