DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12608 and wdr-5.1

DIOPT Version :9

Sequence 1:	NP_573019.1	Gene:	CG12608 / 32463	FlyBaseID:	FBgn0030630	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_497749.1	Gene:	wdr-5.1 / 175474	WormBaseID:	WBGene00006474	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	51/243 - (20%)
Similarity:	95/243 - (39%)	Gaps:	51/243 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EEVLLGFKL-------------IKSPTDGLT----DSVKFELKQTFADSSHAGSITSVAVQWPWV 60
            |..|.|.||             :.|.:|..|    :.|...:.:|....::.....:...|...|
Worm   122 ERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLV 186

  Fly    61 ASGGTDDRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSHLLSGSDDGHMIATRVGSWTKEGDW 125
            .||..|:.:.::|::|....:.:.:|:..|:.:.|..|.|.:.|||.||   ..|:        |
Worm   187 VSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDG---LVRI--------W 240

  Fly   126 QKAHAGQA-----------VTHISCHPSSKLALSLGGDQVLNTWNLVNGRVAYK-TNLKNKATLG 178
            ..|: ||.           |..:...|:.|..|:...|..|..|:...|:...: |..:|...
Worm   241 DTAN-GQCIKTLVDDENPPVAFVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTGHENSKY-- 302

  Fly   179 LQPGCL--SWSKQGDHFTLSG--PLVLEIWGIENAHVMRRIEMPAKPI 222
                |:  ::|..|..:.:||  ...:.||.::...:::.:|...:|:
Worm   303 ----CIFANFSVTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPV 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12608	NP_573019.1	WD40	33..>289	CDD:225201	43/206 (21%)
		WD40	45..295	CDD:295369	41/194 (21%)
		WD40 repeat	51..85	CDD:293791	7/33 (21%)
		WD40 repeat	90..128	CDD:293791	11/37 (30%)
		WD40 repeat	135..170	CDD:293791	7/35 (20%)
		WD40 repeat	181..214	CDD:293791	7/36 (19%)
		WD40 repeat	264..286	CDD:293791
wdr-5.1	NP_497749.1	WD40	<76..372	CDD:225201	51/243 (21%)
		WD40	79..373	CDD:238121	51/243 (21%)
		WD40 repeat	90..127	CDD:293791	2/4 (50%)
		WD40 repeat	133..169	CDD:293791	5/35 (14%)
		WD40 repeat	174..210	CDD:293791	7/35 (20%)
		WD40 repeat	217..252	CDD:293791	13/46 (28%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	303..340	CDD:293791	7/36 (19%)
		WD40 repeat	346..372	CDD:293791	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840