DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9123 and MAK11

DIOPT Version :9

Sequence 1:	NP_573018.1	Gene:	CG9123 / 32462	FlyBaseID:	FBgn0030629	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_012904.3	Gene:	MAK11 / 853847	SGDID:	S000001504	Length:	468	Species:	Saccharomyces cerevisiae

Alignment Length:	429	Identity:	115/429 - (26%)
Similarity:	188/429 - (43%)	Gaps:	78/429 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EMEIIEATNEELLLGFKLIKSPTDGFTDSVKF-ELKQTFADSSYARSITSLAVQWPWVASGGTDG 67
            :..||..:.|..:|...| ..|.....|:.|. .....|...:::.||..|||...::.||..|.
Yeast    63 QFRIIVGSYEHNILCLSL-DIPNQKENDAAKTPHFMPIFHFQAHSLSIKCLAVSRRYLVSGSNDE 126

  Fly    68 RIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLS---------------LLLSGSDDGHMIATRVG 117
            .|.:||::.||:...:|||.|.:..|:|:...|               .|||.|:|..::..||.
Yeast   127 HIRIYDLQKRKELGTLLSHQGSITALQFSHPASSSEDAAVSKGSKNSKWLLSASEDHKIMVWRVK 191

  Fly   118 SWTKEYDWQKAHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKNKATL---DF 179
            .| :.....|.|..: |..|..||::::|:|:..|..:..|||:        .|:|.|.|   .:
Yeast   192 DW-ETVGTLKGHTAR-VNDVDIHPTNRIAISVSDDHSIRLWNLM--------TLRNAAVLKLRKY 246

  Fly   180 QTG--CLSW-SKQGDHFTLSGPLVLEIWGIENAHVMRRIEMPSKPIC-----ITWLDGNECLT-G 235
            .|.  |:.| ..:||:|.:.....:.|:...:|.|.:.|....|.:.     |...|..|.|: |
Yeast   247 NTNGTCVRWLGAKGDYFAVGLRDRVLIYETGSAKVFKEIVFQRKTLMHIETHILPFDNKEYLSVG 311

  Fly   236 LDNGNIAWISLK----------------DEDDTPPTF-ILAHEVRVKAIA-YLNEF---LATVSI 279
            :.:||:.:...:                |::|..|.| :|.|..|:|... |.|||   |.|:..
Yeast   312 ISDGNVHFYPCEELFEKVEENEKQEDDDDKEDISPAFSLLGHTNRIKDFKFYTNEFGTYLVTIGS 376

  Fly   280 AGQIKVWKIDMETRKLEEIARSFMDC--RPTDLGLLD--LRQFGNVRPVEQRTKVEEKPKAKVES 340
            .|:|.||  ||.|:  |::|  ..||  |...|.|.|  :.::..::..:..| .:...:::|||
Yeast   377 DGKIVVW--DMSTK--EQVA--VYDCGERLNCLTLCDESIEKYNTMKKRDAET-ADIGDQSEVES 434

  Fly   341 DQSAKPAAPRGFVTIEYEQDKKLDAEKKKEKKKNKKDEE 379
            |...       ...|.:.:.|||:.:|:|:.||:|...|
Yeast   435 DTEE-------LKKIMFGEKKKLNKKKRKQLKKSKVSVE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9123	NP_573018.1	WD40	49..295	CDD:295369	83/293 (28%)
		WD40 repeat	50..85	CDD:293791	12/34 (35%)
		WD40	<60..294	CDD:225201	78/281 (28%)
		WD40 repeat	91..129	CDD:293791	12/52 (23%)
		WD40 repeat	134..170	CDD:293791	10/35 (29%)
		WD40 repeat	178..216	CDD:293791	9/40 (23%)
		WD40 repeat	222..257	CDD:293791	11/57 (19%)
		WD40 repeat	264..288	CDD:293791	11/27 (41%)
MAK11	NP_012904.3	WD40	98..384	CDD:421866	81/297 (27%)
		WD40 repeat	109..144	CDD:293791	12/34 (35%)
		WD40 repeat	150..201	CDD:293791	11/51 (22%)
		WD40 repeat	206..242	CDD:293791	13/43 (30%)
		WD40 repeat	251..286	CDD:293791	8/34 (24%)
		WD40 repeat	293..351	CDD:293791	11/57 (19%)
		WD40 repeat	359..385	CDD:293791	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39574
Inparanoid	1	1.050	107	1.000	Inparanoid score	I1405
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm46561
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	1	1.100	-	-	O	PTHR44675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1339
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850