DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9123 and PAK1IP1

DIOPT Version :9

Sequence 1:	NP_573018.1	Gene:	CG9123 / 32462	FlyBaseID:	FBgn0030629	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	XP_011513022.1	Gene:	PAK1IP1 / 55003	HGNCID:	20882	Length:	415	Species:	Homo sapiens

Alignment Length:	423	Identity:	105/423 - (24%)
Similarity:	181/423 - (42%)	Gaps:	86/423 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KFELKQTFADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPD 98
            ::.|...|...::..|::::||...:|.:|..|..|.:|||:.:.:...::.|:|.:..|||..:
Human    52 QWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGN 116

  Fly    99 LSLLLSGSDDGHMIATRVGSWTKEYDWQ-----KAHAGQAVTHVSCHPSSKLALSLGGDQVLNTW 158
            .. |:||::||     .:..|..: .|:     |||.|| ||.:|.|||.|||||:|.|:.|.||
Human   117 RH-LISGAEDG-----LICIWDAK-KWECLKSIKAHKGQ-VTFLSIHPSGKLALSVGTDKTLRTW 173

  Fly   159 NLVNGCVAHKTNLKNKATLDFQTGCLSWSKQGDHFTLSGPLVLEIWGIENAHVMRRIEMPSKPIC 223
            |||.|..|...|:|..|.:      :.||.:|:.:.:.....::|:.::.|.:...|....:...
Human   174 NLVEGRSAFIKNIKQNAHI------VEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISS 232

  Fly   224 ITWLDGNECLTGLDNGNIAWISLKDEDDTPPTFIL----AHEVRVKAIAYL----NEFLATVSIA 280
            :.:|..:......|...|.:.      |......|    |||.|||.:...    :..:.:.|..
Human   233 VKFLSESVLAVAGDEEVIRFF------DCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSD 291

  Fly   281 GQIKVWKIDMETRKLEEIARSFM-----DCRPTDLGL-LDLRQFGNVRPVEQRTKVEEKPKAKVE 339
            |.||:||:..:    :::..|.:     :.|.|.||: ||              ||       .:
Human   292 GFIKMWKLKQD----KKVPPSLLCEINTNARLTCLGVWLD--------------KV-------AD 331

  Fly   340 SDQSAKPAAPRGFVTIEYEQDKKLDAEKKKEKKKNKKDEESSEESNSSEDKENDDFSDSDSDVSS 404
            ..:|..|||          :...:..|:.|..||...|....||..|..:.:....:......:.
Human   332 MKESLPPAA----------EPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATK 386

  Fly   405 DHG---HRKRKPMKREQQPTPASKGKAKQQKKK 434
            :.|   .:|||.::..::         |::|||
Human   387 ESGLISTKKRKMVEMLEK---------KRKKKK 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9123	NP_573018.1	WD40	49..295	CDD:295369	74/258 (29%)
		WD40 repeat	50..85	CDD:293791	9/34 (26%)
		WD40	<60..294	CDD:225201	71/246 (29%)
		WD40 repeat	91..129	CDD:293791	11/42 (26%)
		WD40 repeat	134..170	CDD:293791	21/35 (60%)
		WD40 repeat	178..216	CDD:293791	5/37 (14%)
		WD40 repeat	222..257	CDD:293791	4/34 (12%)
		WD40 repeat	264..288	CDD:293791	7/27 (26%)
PAK1IP1	XP_011513022.1	WD40	<60..300	CDD:225201	74/259 (29%)
		WD40	64..298	CDD:295369	72/253 (28%)
		WD40 repeat	68..103	CDD:293791	9/34 (26%)
		WD40 repeat	109..144	CDD:293791	10/41 (24%)
		WD40 repeat	149..185	CDD:293791	21/35 (60%)
		WD40 repeat	193..223	CDD:293791	5/29 (17%)
		WD40 repeat	230..265	CDD:293791	5/40 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39574
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4620
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59992
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm40510
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1339
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.770