DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9123 and pak1ip1

DIOPT Version :9

Sequence 1:	NP_573018.1	Gene:	CG9123 / 32462	FlyBaseID:	FBgn0030629	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001017054.2	Gene:	pak1ip1 / 549808	XenbaseID:	XB-GENE-492186	Length:	365	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	116/406 - (28%)
Similarity:	187/406 - (46%)	Gaps:	71/406 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPEMEIIEATNEELLLGFKLIKSPTDGFTDSVKFELKQTFADSSYARSITSLAVQWPWVASGGT 65
            |...||::....|::|.|:::.:......:.:       .|...::..|::.:||...:||:|..
Frog     1 MEEYMELVVGCYEQVLFGYRVHREGEQWLSSA-------DFTHHAHTASLSVVAVNNRFVATGSK 58

  Fly    66 DGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSW-TKEYDWQ--- 126
            |..|.:|||:.:.:...:|.|.|.:..|:|..: :.||||::||.:..     | ||:::.|
Frog    59 DETIQIYDMKKKVEHGALLHHNGTITCLQFYGN-THLLSGAEDGLICV-----WNTKKWECQQTF 117

  Fly   127 KAHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKNKATLDFQTGCLSWSKQGD 191
            |||.|| |..:|.|||.|||||:|.|:.|.|||||.|..|...|:|..|.:      :.||..||
Frog   118 KAHKGQ-VLSLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKKNAHI------VQWSPSGD 175

  Fly   192 HFTLSGPLVLEIWGIENAHVMRRIEMPSKPICITWL-DGNECLTGLDNGNIAWISLKDED----- 250
            .:.:.....::::.:|.|.|:..|..|.:...:.:: |....:.|            ||:
Frog   176 KYVVVIHDKVDVYQLETAAVIGTINNPKRISSVQFITDALIAVAG------------DEEVIRLY 228

  Fly   251 DTPPTFIL----AHEVRVK--AIAYLNEFLATVSIA--GQIKVWKIDMETRK-----LEEIARSF 302
            ||.....:    |||.|||  .:..|.|....||.:  |.:|:|.||.|..|     |.|::.|
Frog   229 DTASQKCVCEFKAHENRVKNLHVFELEETHIVVSSSSDGFVKMWGIDTEKVKTPPSLLCEVSTS- 292

  Fly   303 MDCRPTDLGL-----LDLRQFGNVRPVEQRTKVEEKPKAKVESDQSA--KPAAPRGFVTIEYEQD 360
              .|.|.|.:     :|.::..|........|..::||.|:...::|  |.|.....:      .
Frog   293 --ARLTCLSVWLPSAVDHKEEANRDVTASTVKDCDRPKKKMTQSKTAENKEAGETQVI------H 349

  Fly   361 KKLDAEKKKEKKKNKK 376
            ||...|.|::|||..|
Frog   350 KKRKLETKQKKKKPMK 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9123	NP_573018.1	WD40	49..295	CDD:295369	86/268 (32%)
		WD40 repeat	50..85	CDD:293791	10/34 (29%)
		WD40	<60..294	CDD:225201	82/251 (33%)
		WD40 repeat	91..129	CDD:293791	13/41 (32%)
		WD40 repeat	134..170	CDD:293791	20/35 (57%)
		WD40 repeat	178..216	CDD:293791	7/37 (19%)
		WD40 repeat	222..257	CDD:293791	6/40 (15%)
		WD40 repeat	264..288	CDD:293791	9/27 (33%)
pak1ip1	NP_001017054.2	WD40	<35..294	CDD:225201	89/286 (31%)
		WD40	39..272	CDD:238121	81/257 (32%)
		WD40 repeat	43..78	CDD:293791	10/34 (29%)
		WD40 repeat	84..119	CDD:293791	12/40 (30%)
		WD40 repeat	124..160	CDD:293791	20/35 (57%)
		WD40 repeat	168..200	CDD:293791	7/31 (23%)
		WD40 repeat	205..240	CDD:293791	6/46 (13%)
		WD40 repeat	248..288	CDD:293791	12/39 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H39574
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010