DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9123 and Pak1ip1

DIOPT Version :9

Sequence 1:	NP_573018.1	Gene:	CG9123 / 32462	FlyBaseID:	FBgn0030629	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001032433.1	Gene:	Pak1ip1 / 361232	RGDID:	1565353	Length:	382	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	119/457 - (26%)
Similarity:	194/457 - (42%)	Gaps:	103/457 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MEIIEATNEELLLGFKLIKSPTDGFTDSVKFELKQT------FADSSYARSITSLAVQWPWVASG 63
            ||::..:.|::|.||.:.:.|       .|...::|      |...::..|::::|....:|.:|
  Rat     1 MELVAGSYEQVLFGFTVHRGP-------AKSGHRETWTPVADFTHHAHTASLSAVAANNRYVVTG 58

  Fly    64 GTDGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSWTKEYDWQ-- 126
            ..|..|.:|||:.:.:...::.|:|.|..|||..... |:||::||.:..     |..: .|:
  Rat    59 SKDETIHIYDMKKKVEHGALVHHSGTVTCLKFYGSRH-LISGAEDGLICV-----WDAK-KWECL 116

  Fly   127 ---KAHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKNKATLDFQTGCLSWSK 188
               |||.|. ||.:|.|||.|||||:|.|:.|.|||||.|..|...|:|..|.:      :.||.
  Rat   117 KSIKAHRGH-VTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHI------VEWSP 174

  Fly   189 QGDHFTLSGPLVLEIWGIENAHVMRRIEMPSKPICITWLDGNECLTGLDNGNIAWISLKDEDDTP 253
            .|:.:.:.....::::.::.|.|...:....:...||:|..:......|...:.:.   |.|
  Rat   175 NGEKYVVVVMNKVDVYHLDTASVSGTLTNGKRISAITFLSDSVLAVAGDEEVVRFF---DCD--- 233

  Fly   254 PTFIL-----AHEVRVKAIAYL----NEFLATVSIAGQIKVWKIDMETRKLEE-IARSFMDCRPT 308
             |.:.     |||.|||.:...    :..|.|.|..|.||:|.:..:.:.... :..:....|.|
  Rat   234 -TLVCLCEFKAHENRVKDMVSFEIPDHHVLVTASNDGFIKMWTLTQDKKAPPSLLCETNTGARLT 297

  Fly   309 DLGL-LDLRQFGNVRPVEQRTKVEEKPKAKVESDQSAKPAAPRGFVTIEYEQDKKLDAEKKKEKK 372
            .||: ||       |..::        ||::.......|..|:   |||.|
  Rat   298 CLGVWLD-------RGTDE--------KARLPPATEPCPDQPK---TIEKE-------------- 330

  Fly   373 KNKKDEESSEESNSSEDKENDDFSDSDSDVSSDHGHRKRKPMKREQQPTPASKGK-----AKQQK 432
                          |.||..::.|..::: .|||....::|.|| ..|.||.|.|     .|::|
  Rat   331 --------------SADKIQEEASAPNAE-KSDHTGGSQQPTKR-NSPAPAKKRKMANVSEKKRK 379

  Fly   433 KK 434
            ||
  Rat   380 KK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9123	NP_573018.1	WD40	49..295	CDD:295369	75/259 (29%)
		WD40 repeat	50..85	CDD:293791	8/34 (24%)
		WD40	<60..294	CDD:225201	73/247 (30%)
		WD40 repeat	91..129	CDD:293791	11/42 (26%)
		WD40 repeat	134..170	CDD:293791	21/35 (60%)
		WD40 repeat	178..216	CDD:293791	5/37 (14%)
		WD40 repeat	222..257	CDD:293791	7/34 (21%)
		WD40 repeat	264..288	CDD:293791	9/27 (33%)
Pak1ip1	NP_001032433.1	WD40	<37..274	CDD:225201	74/257 (29%)
		WD40	41..274	CDD:295369	74/253 (29%)
		WD40 repeat	45..80	CDD:293791	8/34 (24%)
		WD40 repeat	86..121	CDD:293791	10/41 (24%)
		WD40 repeat	126..162	CDD:293791	21/35 (60%)
		WD40 repeat	207..242	CDD:293791	7/41 (17%)
		WD40 repeat	250..291	CDD:293791	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39574
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4554
OMA	1	1.010	-	-		QHG59992
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm44652
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.740