DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9123 and pak1ip1

DIOPT Version :9

Sequence 1:	NP_573018.1	Gene:	CG9123 / 32462	FlyBaseID:	FBgn0030629	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_957239.2	Gene:	pak1ip1 / 336470	ZFINID:	ZDB-GENE-030131-8414	Length:	368	Species:	Danio rerio

Alignment Length:	400	Identity:	112/400 - (28%)
Similarity:	189/400 - (47%)	Gaps:	69/400 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPEMEIIEATNEELLLGFKLIKSPTDGFTDSVKFELKQTFADSSYARSITSLAVQWPWVASGGT 65
            |...:|::....|:::.|:::  .|.|     .::.::.||...::..|:.:::....::|:|..
Zfish     8 MGDHIELVAGCYEQIVFGYRV--CPAD-----EEWTIEPTFTHHAHTASLNAVSSSNQFIATGSK 65

  Fly    66 DGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLSLLLSGSDDGHMIATRVGSW-TKEYDWQK-- 127
            |..|.:|||..:.:...:|.|.|.::.|:|. ..|.||||..||.:..     | ||:::..|
Zfish    66 DETIQLYDMCKKTEHGALLHHDGTISCLEFY-GTSHLLSGGQDGLICV-----WSTKKWECLKTI 124

  Fly   128 -AHAGQAVTHVSCHPSSKLALSLGGDQVLNTWNLVNGCVAHKTNLKNKATLDFQTGCLSWSKQGD 191
             ||.|| ||.:|.|||.|||||:|.|:.|.||||:.|..|...|:|..|.:      :.||..||
Zfish   125 RAHKGQ-VTSLSVHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKQNAEI------VLWSPDGD 182

  Fly   192 HFTLSGPLVLEIWGIENAHVMRRIEMPSKPICITWLDGNECLTGLDNGNIAWISLKDEDDTPPTF 256
            .:.:.....::|:.:::|.::..|....:..|:.:|..:....|.|:.     |::..|.|....
Zfish   183 KYAVVVNDKVDIYTLDSATIIGTIAFTKRISCLKFLKNSLLAVGGDDE-----SVRIYDVTSQKC 242

  Fly   257 IL---AHEVRVKAI-AYLNE---FLATVSIAGQIKVWKIDMETRKLEEIARSFMDCRPTDLGLLD 314
            :.   |||.||||| :::.:   .|.|.|..|.||:||:::|:  :|.         ||.||.|:
Zfish   243 VCEFKAHENRVKAIESFMKDDFCVLVTASNDGFIKLWKLNLES--IES---------PTLLGQLN 296

  Fly   315 LRQFGNVR--------PVEQRTKVEEKPKAKVESDQSAKPAAP---------RGFVTIEYEQDKK 362
            .    ..|        |.|.: :..|:|.....|:....|..|         ...|.:|.|:..|
Zfish   297 T----TARLTCLCVWMPGETK-ETAEQPAQATTSEDVLDPLVPVRSKRVRILGEEVIMEDEKGSK 356

  Fly   363 LDAEKKKEKK 372
            ...:|||.:|
Zfish   357 TQGKKKKRQK 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9123	NP_573018.1	WD40	49..295	CDD:295369	82/256 (32%)
		WD40 repeat	50..85	CDD:293791	7/34 (21%)
		WD40	<60..294	CDD:225201	81/244 (33%)
		WD40 repeat	91..129	CDD:293791	13/41 (32%)
		WD40 repeat	134..170	CDD:293791	20/35 (57%)
		WD40 repeat	178..216	CDD:293791	6/37 (16%)
		WD40 repeat	222..257	CDD:293791	7/34 (21%)
		WD40 repeat	264..288	CDD:293791	11/27 (41%)
pak1ip1	NP_957239.2	WD40	<36..288	CDD:225201	84/271 (31%)
		WD 1	45..82		8/36 (22%)
		WD40	46..280	CDD:238121	79/251 (31%)
		WD40 repeat	49..85	CDD:293791	8/35 (23%)
		WD 2	85..123		14/43 (33%)
		WD40 repeat	90..125	CDD:293791	13/40 (33%)
		WD 3	126..165		24/39 (62%)
		WD40 repeat	132..167	CDD:293791	19/34 (56%)
		WD 4	207..245		7/42 (17%)
		WD40 repeat	212..237	CDD:293791	5/29 (17%)
		WD 5	248..289		18/51 (35%)
		WD40 repeat	253..279	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0294
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39574
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4491
OMA	1	1.010	-	-		QHG59992
OrthoDB	1	1.010	-	-		D537718at33208
OrthoFinder	1	1.000	-	-		FOG0005831
OrthoInspector	1	1.000	-	-		otm26090
orthoMCL	1	0.900	-	-		OOG6_103104
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1339
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.770