Protein Alignment HDAC6 and HDAC4

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_011510519.1
• Gene: HDAC4 / 9759
• HGNCID: 14063
• Length: 1113
• Species: Homo sapiens
• Alignment Length: 1034
• Identity: 269/1034 - (26%)
• Similarity: 404/1034 - (39%)
• Gaps: 273/1034 - (26%)

  Fly     2 SPPIVTRRSAQQAKIQTR---------------AMASKSKTGTTGAATAAGGTGSSSGSISGGFN 51
            |.|.:..||..:.|:..|               |:..:....|..|.::|.|:|.||.:.|.|..
Human   270 SEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSV 334

  Fly    52 AADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQ 116
            :|:  ....|....:.|:....:.::..:|..:                    |..|....|:.
Human   335 SAE--NGIAPAVPSIPAETSLAHRLVAREGSAA--------------------PLPLYTSPSLP- 376

  Fly   117 HCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRD 181
                                      |:|   |.||:...:..                |:|.:|
Human   377 --------------------------NIT---LGLPATGPSAG----------------TAGQQD 396

  Fly   182 DERMEELSSRYDSIYIHPSTFELSLLASGSTIE---------LVDHLVAGKAQNGMAIIRPPGHH 237
            .||: .|.:....:.:.|.| .|:...|.|.:|         |:.|:|        .:.:||...
Human   397 AERL-TLPALQQRLSLFPGT-HLTPYLSTSPLERDGGAAHSPLLQHMV--------LLEQPPAQA 451

  Fly   238 AMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHG 302
            .:..::    :.:.:.....||..:....|:.
Human   452 PLVTDW----YLSGLGALPLHAQSLVGADRVS--------------------------------- 479

  Fly   303 SFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAI---FQQLLLPVALEFQPELIIVSA 364
               |.:|:...|   ...|...:..:|.||..:   .:|.|   .||.|.....:||.:.:.:
Human   480 ---PSIHKLRQH---RPLGRTQSAPLPQNAQAL---QHLVIQQQHQQFLEKHKQQFQQQQLQM-- 533

  Fly   365 GYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSL--------AEGAALTLR 421
              :..:..| .|....|..:|......||...|    :|:..| ||.|        ..|..:...
Human   534 --NKIIPKP-SEPARQPESHPEETEEELREHQA----LLDEPY-LDRLPGQKEAHAQAGVQVKQE 590

  Fly   422 SLLGD--PCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVL 484
            .:..|  ...|..|..|..|....|.||.       ..:.|.|:|             :.:|. |
Human   591 PIESDEEEAEPPREVEPGQRQPSEQELLF-------RQQALLLEQ-------------QRIHQ-L 634

  Fly   485 RHW------------IGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYA 537
            |::            .||..|:.|..:...:...|          :.|....||   |.|.....
Human   635 RNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFP----------VSVQEPPTK---PRFTTGLV 686

  Fly   538 YDAQMLLH-CNL-NDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH--- 597
            ||..||.| |.. :.:.|||...|||.|.....:.||..:.:.:..|.||.:|:...|:.||
Human   687 YDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLL 751

  Fly   598 --VNTVRRLLGREPKELHDAAGIY------------NSVYLHPRTFDCATLAAGLVLQAVDSVLR 648
              .|.:.|......|.|...|.::            ::::....:...|.||.|.|::.|..|..
Human   752 YGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT 816

  Fly   649 GESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFE 713
            ||.::|...|||||||||:..|.|||.||:||:||:...:...:.::||||||||||||||..|.
Human   817 GELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFY 881

  Fly   714 SNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLI 775
            |:|.|||:|||||:.|:|||  ..|..|.||.|.|.|||||:.:.   ...|||.||..||:.::
Human   882 SDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVV 944

  Fly   776 MPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNS 838
            ||||.||.|.:||||:||||..|  .||||..::|..:|.||..|..||.|||::.||||:::.:
Human   945 MPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTA 1009

  Fly   839 ISYAMTMCTKTLLG---DPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLE----F 896
            |..|...|...|||   ||:|     ...||:.|..   :.|.|:::.:::...:||.|:    .
Human  1010 ICDASEACVSALLGNELDPLP-----EKVLQQRPNA---NAVRSMEKVMEIHSKYWRCLQRTTST 1066

  Fly   897 VGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAG-GLAGDRPDCGDERPSGSKP 954
            .||.| .:....||...:.:||.          |:.:.| ..|..||   ||.|...:|
Human  1067 AGRSL-IEAQTCENEEAETVTAM----------ASLSVGVKPAEKRP---DEEPMEEEP 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	60/359 (17%)
		HDAC6-dom2	538..895	CDD:212527	153/383 (40%)
		zf-UBP	1007..1069	CDD:460464
HDAC4	XP_011510519.1	ClassIIa_HDAC4_Gln-rich-N	<115..176	CDD:197398
		HDAC4	678..1086	CDD:212530	162/421 (38%)