Protein Alignment HDAC6 and HDAC3

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001341968.1
• Gene: HDAC3 / 8841
• HGNCID: 4854
• Length: 434
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 86/333 - (25%)
• Similarity: 157/333 - (47%)
• Gaps: 29/333 - (8%)

  Fly   534 VCYAYDAQMLLHCNLN-DTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 597
            |.|.||..:   .|.: ..|||.:|.|:...|.:...|||.|:|....|..|:..::|..|:..:
Human     5 VAYFYDPDV---GNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDY 66

  Fly   598 VNTVRRLLGREPKELH------DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGIC 656
            ::.::|:   .|..:.      :|..:.:...:.|..|:..:...|..||....:     .:.||
Human    67 IDFLQRV---SPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQL-----NNKIC 123

  Fly   657 NVR---PPG-HHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPK 717
            ::.   ..| |||::....|||..|::.|.....::..  .|||.:|.|:|||:|.|..|....:
Human   124 DIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDR 186

  Fly   718 VLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEF 782
            |:.:|.|:|  |::|..| .|:...||..:||.:.:|:|. :.|:.|..|...||.:|..:...:
Human   187 VMTVSFHKY--GNYFFPG-TGDMYEVGAESGRYYCLNVPL-RDGIDDQSYKHLFQPVINQVVDFY 247

  Fly   783 NPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCT 847
            .|..:::..|.|:...|.||...::..|:|....::.:. :..::|...|||.|.:::...|..|
Human   248 QPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSF-NIPLLVLGGGGYTVRNVARCWTYET 311

  Fly   848 KTLLGDPV 855
            ..|:.:.:
Human   312 SLLVEEAI 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	84/329 (26%)
		zf-UBP	1007..1069	CDD:460464
HDAC3	NP_001341968.1	HDAC3	3..383	CDD:212529	86/333 (26%)
		Histone deacetylase	3..316		86/328 (26%)