Protein Alignment HDAC6 and HOS1

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_015393.1
• Gene: HOS1 / 856181
• SGDID: S000006272
• Length: 470
• Species: Saccharomyces cerevisiae
• Alignment Length: 315
• Identity: 76/315 - (24%)
• Similarity: 134/315 - (42%)
• Gaps: 49/315 - (15%)

  Fly   550 DTGHPEQPSRIQHIHKMHD------DYGLLKQMKQLSPR------------AATTDEVCLAHTRA 596
            |..:|...|:...:.::.|      ||...:.:::.:.|            |...:..|:.::..
Yeast    81 DVNNPMVESKWSELSELADNWNEKIDYNPSQDLQRFTTRENLYNYYLNHSQALENNMDCINNSEV 145

  Fly   597 HVN---TVRRLLGREPKE--LHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGIC 656
            ..|   |...:|..|.|:  |.....|::.:.::     |..: .|..|..:|.:...|...||
Yeast   146 PTNDKPTDTYILNSETKQYNLEGDCPIFSYLPMY-----CQVI-TGATLNLLDHLSPTERLIGI- 203

  Fly   657 NVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYI 721
            |.....|||.:....|||..|:|.:..| .:|...|.::..||:|:|||:|.:..|:.:.::..|
Yeast   204 NWDGGRHHAFKQRASGFCYINDVVLLIQ-RLRKAKLNKITYVDFDLHHGDGVEKAFQYSKQIQTI 267

  Fly   722 SLHRYEHGSFFPKGPDGNFDVVGKG----AGRGFN-VNIPWNKKGMGDLEYALAFQQLIMPIAYE 781
            |:|.||.| |||          |.|    :.:..| ||||. |.|..|....|...:::.|:...
Yeast   268 SVHLYEPG-FFP----------GTGSLSDSRKDKNVVNIPL-KHGCDDNYLELIASKIVNPLIER 320

  Fly   782 FNPQLVLVSAGFDAAIGDPLGGCKVTAEGYG-MLTHWLSALASGRIIVCLEGGYN 835
            ..|:.:::..|.|..:||.....::|..|.. ::.:.:.:.....|.:...||||
Yeast   321 HEPEALIIECGGDGLLGDRFNEWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYN 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	76/315 (24%)
		zf-UBP	1007..1069	CDD:460464
HOS1	NP_015393.1	HDAC_Hos1	5..390	CDD:212543	76/315 (24%)