DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and HOS3

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_015209.1	Gene:	HOS3 / 855987	SGDID:	S000006037	Length:	697	Species:	Saccharomyces cerevisiae

Alignment Length:	398	Identity:	97/398 - (24%)
Similarity:	153/398 - (38%)	Gaps:	96/398 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 PEKLTSNAARLQVLRAETKLSVPSFKVCYA---YDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDD 569
            |.:..:.:.|..::....:|...|..:..|   |.:...|..:....|....|    |:.|:|.
Yeast    56 PREWVTKSYRKTIVERPERLLASSMGISAAITMYPSLFTLKSSHQRKGSLMAP----HVLKVHG- 115

  Fly   570 YGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNS--VYLHPRTFDCA 632
                      |...|...|:|      .:...:.|.|.  .|:.|.   :||  :||..:|....
Yeast   116 ----------SSWPAELIELC------QMADAKLLKGE--IEVPDT---WNSGDIYLSSKTIKAL 159

  Fly   633 TLAAGLVLQAVDSVLRGESRSGICN-----VRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGL 692
            ....|.:...|||:.:|.|...|.|     :||||||.....|.|||:.||..:|.:||...:.:
Yeast   160 QGTIGAIETGVDSIFKGPSAEHISNRAFVAIRPPGHHCHYGTPSGFCLLNNAHVAIEYAYDTYNV 224

  Fly   693 ERVLIVDWDVHHGNGTQHI------------------------FESNPKVLYISLHRYEHGSFFP 733
            ..|:::|:|:|||:|||.|                        |...|||.|.|:|  :..||..
Yeast   225 THVVVLDFDLHHGDGTQDICWKRAGFKPEEEPEDSSYDDFGKKFAEFPKVGYFSMH--DINSFPT 287

  Fly   734 KGPDGNFDVVGKGAG----RGFNVNIPWN---KKGMGDLEYALAFQ-----------QLIMPIAY 780
            :......:.: |.|.    ...::|| ||   .|...:.|:.:.::           :.......
Yeast   288 ESGFATKENI-KNASTCIMNSHDLNI-WNIHLSKWTTEEEFNVLYRTKYRTLFAKADEFFRSAKL 350

  Fly   781 EFNPQ------LVLVSAGFDAAIGDPLG----GCKVTAEGYGMLTHWLSALAS----GRIIVCLE 831
            |.|.|      ||::||||||:..:...    ...|....|...|.....||.    |:::..:|
Yeast   351 EMNQQGRPFKGLVVISAGFDASEFEQTSMQRHSVNVPTSFYTTFTKDALKLAQMHCHGKVLSLME 415

  Fly   832 GGYNVNSI 839
            |||:..:|
Yeast   416 GGYSDKAI 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	92/365 (25%)
		zf-UBP	1007..1069	CDD:280334
HOS3	NP_015209.1	HDAC_Hos3	47..435	CDD:212522	97/398 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810