DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and HDA1

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_014377.1	Gene:	HDA1 / 855710	SGDID:	S000004966	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	428	Identity:	154/428 - (35%)
Similarity:	235/428 - (54%)	Gaps:	43/428 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 TSNAARLQVL--RAETKLSVPSFKVCYAYDAQMLLHCNLNDT------GHPEQPSRIQHIHKMHD 568
            |::.::.||:  ....|:.....|....||.:|..|..:..:      .|||.|.||..|:|:..
Yeast    34 TTSKSKRQVIVPVCMPKIHYSPLKTGLCYDVRMRYHAKIFTSYFEYIDPHPEDPRRIYRIYKILA 98

  Fly   569 DYGLLKQ------------MKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNS 621
            :.||:..            |.::..||||::|:...||:.|:..:........:||.......:|
Yeast    99 ENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEFIESTEKMSREELLKETEKGDS 163

  Fly   622 VYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYA 686
            ||.:..::..|.|..|..::|..:|:.|..::.:..|||||||||.....|||:|:|||:||:..
Yeast   164 VYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPGHHAEPQAAGGFCLFSNVAVAAKNI 228

  Fly   687 IRDF--GLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGR 749
            ::::  .:.|::|:|||:|||||||..|..:.:|||:||||:|.|.::|....|.:|..|:|.|.
Yeast   229 LKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGE 293

  Fly   750 GFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGML 814
            |||.||.|...|:||.||..||:|::||:..||.|.||::|:|||||.||.:|.|.||...||.:
Yeast   294 GFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHM 358

  Fly   815 THWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDP---VPTPQLGATALQKP-PTVAFQS 875
            ||.|.:||.|.:.|.||||||:::|:.:.....|.|:|:|   :|.|      |..| |.|
Yeast   359 THMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIGEPPDELPDP------LSDPKPEV---- 413

  Fly   876 CVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNE 913
             :|.:.:.:::|..:|...    ||  |....|.|.||
Yeast   414 -IEMIDKVIRLQSKYWNCF----RR--RHANSGCNFNE 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	142/380 (37%)
		zf-UBP	1007..1069	CDD:280334
HDA1	NP_014377.1	HDAC_Clr3	81..403	CDD:212542	129/321 (40%)
HDA1	NP_014377.1	Arb2	457..698	CDD:401634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345824
Domainoid	1	1.000	255	1.000	Domainoid score	I327
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	1	1.000	-	-		oto99496
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X2174
TreeFam	1	0.960	-	-
	11	10.730