DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and RPD3

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_014069.1	Gene:	RPD3 / 855386	SGDID:	S000005274	Length:	433	Species:	Saccharomyces cerevisiae

Alignment Length:	450	Identity:	116/450 - (25%)
Similarity:	196/450 - (43%)	Gaps:	84/450 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   530 PSFK--VCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLA 592
            ||.|  |.|.|||.:..:.  ...|||.:|.||:..|.:..:|||.|:|:....:.||..|:|..
Yeast    15 PSDKRRVAYFYDADVGNYA--YGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQF 77

  Fly   593 HTRAHVNTVRR-------LLGREPKELH--DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLR 648
            ||..:::.:.|       :..||..:.:  |...:::.:|      :..:::.|..::....:.|
Yeast    78 HTDEYIDFLSRVTPDNLEMFKRESVKFNVGDDCPVFDGLY------EYCSISGGGSMEGAARLNR 136

  Fly   649 GESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFE 713
            |:....: |.....|||::....|||..|::.:.....:|..  .|||.:|.|||||:|.:..|.
Yeast   137 GKCDVAV-NYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYH--PRVLYIDIDVHHGDGVEEAFY 198

  Fly   714 SNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPI 778
            :..:|:..|.|:|  |.|||  ..|....:|.|||:.:.||:|. :.|:.|..|...|:.:|..|
Yeast   199 TTDRVMTCSFHKY--GEFFP--GTGELRDIGVGAGKNYAVNVPL-RDGIDDATYRSVFEPVIKKI 258

  Fly   779 AYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAM 843
            ...:.|..|::..|.|:..||.||...::.||:....:::.:.....::|. .|||.:.::  |.
Yeast   259 MEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVG-GGGYTMRNV--AR 320

  Fly   844 TMCTKT------LLGDPVP-------------------------TPQLGATALQKPPTVAFQSCV 877
            |.|.:|      :|...:|                         ||:.    |.|..|..|.: :
Yeast   321 TWCFETGLLNNVVLDKDLPYNEYYEYYGPDYKLSVRPSNMFNVNTPEY----LDKVMTNIFAN-L 380

  Fly   878 ESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTAS--------LRHLNISNDD 929
            |:.:....||.||          .|||.....:..||...|.        .|.|::.:|:
Yeast   381 ENTKYAPSVQLNH----------TPRDAEDLGDVEEDSAEAKDTKGGSQYARDLHVEHDN 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	102/396 (26%)
		zf-UBP	1007..1069	CDD:280334
RPD3	NP_014069.1	RPD3-like	18..392	CDD:212528	103/397 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810