DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and HOS2

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_011321.1	Gene:	HOS2 / 852681	SGDID:	S000003162	Length:	452	Species:	Saccharomyces cerevisiae

Alignment Length:	353	Identity:	94/353 - (26%)
Similarity:	160/353 - (45%)	Gaps:	34/353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 ETKLSVPSFKVCYAYDAQMLLHCNLN------DTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPR 582
            :||.:.|.|:...||..::..|.|..      ...||.:|.|:.....:...|||.|.|.....|
Yeast    10 KTKENEPLFEFNSAYSPRVSYHFNSKVSHYHYGVKHPMKPFRLMLTDHLVSSYGLHKIMDLYETR 74

  Fly   583 AATTDEVCLAHTRAHVNTVRRLLGREPKEL----------HDAAGIYNSVYLHPRTFDCATLAAG 637
            :||.||:...|:..:||.:.::......:|          .|...|:.::|      |..||..|
Yeast    75 SATRDELLQFHSEDYVNFLSKVSPENANKLPRGTLENFNIGDDCPIFQNLY------DYTTLYTG 133

  Fly   638 LVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDV 702
            ..|.|...::..:|...| |.....|||:::.|.|||..|::.::....:|..  .|:|.:|.|:
Yeast   134 ASLDATRKLINNQSDIAI-NWSGGLHHAKKNSPSGFCYVNDIVLSILNLLRYH--PRILYIDIDL 195

  Fly   703 HHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEY 767
            |||:|.|..|.:..:|..:|.|:| :|.|||  ..|:...:|...|:.|.:|:|. :.|:.|..|
Yeast   196 HHGDGVQEAFYTTDRVFTLSFHKY-NGEFFP--GTGDLTEIGCDKGKHFALNVPL-EDGIDDDSY 256

  Fly   768 ALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEG 832
            ...|:.::.|:...|.|.|::...|.|:...|.||...:..:.:|....::.:.....::|. .|
Yeast   257 INLFKSIVDPLIMTFKPTLIVQQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVG-GG 320

  Fly   833 GYNVNSIS----YAMTMCTKTLLGDPVP 856
            ||...::|    |...:....||.:.:|
Yeast   321 GYTPRNVSRLWTYETGILNDVLLPEDIP 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	89/339 (26%)
		zf-UBP	1007..1069	CDD:280334
HOS2	NP_011321.1	HDAC_Hos2	28..338	CDD:212540	85/323 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810