DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC6 and Hdac7

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:XP_008764065.1 Gene:Hdac7 / 84582 RGDID:619982 Length:975 Species:Rattus norvegicus


Alignment Length:1099 Identity:280/1099 - (25%)
Similarity:415/1099 - (37%) Gaps:323/1099 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSPPIVTRRSAQQAKIQTRAMASKSKTGTTGAATAAG---------------------------- 37
            |.||:...:.|||.: :.|.:.:|.|:..:..|::..                            
  Rat    73 MDPPLPELQGAQQEQ-ELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIP 136

  Fly    38 -------GTGSSSGSISGGFNAADP------------RKS-NKPNAAL----LEAKRRARNNMLK 78
                   .|..::.|:...|....|            ||: ::||..|    .::..|.:|.:|:
  Rat   137 YRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLR 201

  Fly    79 NQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELN 143
            .:..               ..||.|:|...:.|.|               |...:.....|...|
  Rat   202 KESA---------------PPSLRRRPAETLGDSS---------------PSSSSTPASGCSSPN 236

  Fly   144 LTERCLELPSRSATKDEIL--RLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSL 206
            .:|..   |:.:...:.:|  ||       ||:|||                   :.|.......
  Rat   237 DSEHG---PNPALGSEALLGQRL-------RLQETS-------------------LAPFALPTVS 272

  Fly   207 LASGSTIELVDHLVAGKAQNGMAIIRPPG------------HHAMKAEYNGYCFFNNVALATQHA 259
            |....|:.|.....|...:...:.:.|.|            ||.::.|..|       .|.:   
  Rat   273 LLPAITLGLPAPARADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGG-------TLPS--- 327

  Fly   260 LDVHKLQRILIIDYDVHH-------GQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIG 317
                :||.||::|..|.|       |.|...|.:..|.:....:                     
  Rat   328 ----RLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERL--------------------- 367

  Fly   318 SGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVAL---EFQPELIIVSAGYDAALGCPEGEMEV 379
            ||:|    .:.|||.|........|....||.|:..   ..:|.:.::.    .|:..|:...:.
  Rat   368 SGSG----LHRPLNRTRSEPLPPSATASPLLGPLQPRQDRLKPHVQLIK----TAISPPQRPAKP 424

  Fly   380 TPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQ 444
            :.       .|.||...:...:..:||        |..                  |:....|. 
  Rat   425 SE-------KPRLRQIPSAEDLETDGG--------GVG------------------PMANDGLE- 455

  Fly   445 ALLSCIAVHRPHWR-------CLQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYP---- 498
                    ||...|       .:.||| :..|.|.     |..|...|...|||......|    
  Rat   456 --------HRESGRGPPEGRGAVSLQQ-HQQVPLW-----EQQHLAGRLSQGGPGDSVLLPLAQI 506

  Fly   499 -----TRDTAIPLPPEKLTS--NAARLQVLRAETKLSVPSFKVCYAYDAQMLLH-CNLNDTG-HP 554
                 :|..:.|..|..|.|  ...:.|||.:.   ..|:..:  .||:.||.| |:..|.. ||
  Rat   507 GHRPLSRTQSSPAAPVSLLSPEPTCQTQVLNSS---EAPATGL--VYDSVMLKHQCSCGDNSKHP 566

  Fly   555 EQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHV-----NTVRR----------L 604
            |...|||.|.....:.||..|.:.|..|.|:.:|:...|:..||     |.:.|          |
  Rat   567 EHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGL 631

  Fly   605 LGREPKELHDAAGI---YNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAE 666
            |.:....:....|:   .::::....:.:.|..|||.|......|...|.::|...||||||||:
  Rat   632 LAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHAD 696

  Fly   667 QDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSF 731
            .....|||.||:||||.:...:.....::||||||||||||||..|..:|:||||||||::.|:|
  Rat   697 HSTAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGTQQTFYQDPRVLYISLHRHDDGNF 761

  Fly   732 FPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGF 793
            ||  ..|..|.||.|:|.|||||:.|.   ...|||.||..||:.::||||.||.|.||||||||
  Rat   762 FP--GSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAPDLVLVSAGF 824

  Fly   794 DAAIGD--PLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVP 856
            |||.|.  ||||..|:|:.:|.:|..|.:||.|.:::.||||:::.:|..|...|...|||:.| 
  Rat   825 DAAEGHPAPLGGYHVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGNKV- 888

  Fly   857 TPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGR----RLPRDPVVGENNNEDFLT 917
            .|....:..|||..    :.:.||:..::|.|.:|..::.:..    .|||.|  |.:...:.:|
  Rat   889 DPLSQESWKQKPNL----NAIRSLEAVVRVHRKYWGCMQRLASCPDPWLPRVP--GADAEVEAVT 947

  Fly   918 ASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKPKVKVKTLSDYLAENKEALEQSE 976
            |.          |:.:.|.||.|||                         :||.:|:.|
  Rat   948 AL----------ASLSVGILAEDRP-------------------------SKELMEEEE 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526 60/361 (17%)
HDAC6-dom2 538..895 CDD:212527 152/381 (40%)
zf-UBP 1007..1069 CDD:280334
Hdac7XP_008764065.1 Arginase_HDAC 544..919 CDD:302587 151/383 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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