Protein Alignment HDAC6 and HDAC10

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_114408.3
• Gene: HDAC10 / 83933
• HGNCID: 18128
• Length: 669
• Species: Homo sapiens
• Alignment Length: 814
• Identity: 271/814 - (33%)
• Similarity: 380/814 - (46%)
• Gaps: 178/814 - (21%)

  Fly   106 TALIYDESMSQHCCLWDKEHYEC----PERFTRVLERCRELNLTERCLELPSRSATKDEILRLHT 166
            |||:|.|.|:....|||..  ||    |||.|..|:|.|:..|.:|||.|.:|.|:::|:..:|:
Human     3 TALVYHEDMTATRLLWDDP--ECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHS 65

  Fly   167 EEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAII 231
            .|:...::||. :...|.::.||.::|:||.|||||..:.||:|:.::|||.::.|..|||:|::
Human    66 PEYVSLVRETQ-VLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALV 129

  Fly   232 RPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSI 296
            ||||||..:|..||:|.|||||:|..||...|.|.|||::|:|||||||.|..|.:||.|:|||.
Human   130 RPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSW 194

  Fly   297 HRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELII 361
            ||:|||.|||.|.|||..|:|.|.|.|:..|:|.|..||.|.||:|.|..||||:|.||.|||::
Human   195 HRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVL 259

  Fly   362 VSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGD 426
            ||||:|:|:|.|||:|:.||.|:.||...|..||..||..||||||.|:||||...:|:::||||
Human   260 VSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGD 324

  Fly   427 PCPPLVETVPL-PRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRHWIGG 490
            |.|||  :.|: |.....:::.|..|...|||:.|| ||....|.:.......:         |.
Human   325 PAPPL--SGPMAPCQSALESIQSARAAQAPHWKSLQ-QQDVTAVPMSPSSHSPE---------GR 377

  Fly   491 PPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAY---DAQMLLHCNLNDTG 552
            |||:         :|..|....:.:|...:|........||.:...|.   |..::|
Human   378 PPPL---------LPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVL-------- 425

  Fly   553 HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAG 617
               .|..||.                   .|:...|...|..|.|.:     |.||.
Human   426 ---PPDVIQQ-------------------EASALREETEAWARPHES-----LAREE-------- 455

  Fly   618 IYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIA 682
                          |..|.|.:|..:|.:|.|:..|||.                     ....:
Human   456 --------------ALTALGKLLYLLDGMLDGQVNSGIA---------------------ATPAS 485

  Fly   683 AQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFD------ 741
            |..|..|..:.|.|        .:|.|       ::|.::|.:.:      :.||...|
Human   486 AAAATLDVAVRRGL--------SHGAQ-------RLLCVALGQLD------RPPDLAHDGRSLWL 529

  Fly   742 -VVGKGAG--RGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGG 803
             :.||.|.  ..|:|:.|......|.|...|.   |::|:||.|.|.||||:.|
Human   530 NIRGKEAAALSMFHVSTPLPVMTGGFLSCILG---LVLPLAYGFQPDLVLVALG----------- 580

  Fly   804 CKVTAEGYG-------MLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLG 861
                 .|:|       :|...|..||.||::..||    .||......:..:.|.|:  ..|.||
Human   581 -----PGHGLQGPHAALLAAMLRGLAGGRVLALLE----ENSTPQLAGILARVLNGE--APPSLG 634

  Fly   862 ATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLE 895
                  |.:||....|::|..........|:.|:
Human   635 ------PSSVASPEDVQALMYLRGQLEPQWKMLQ 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	168/342 (49%)
		HDAC6-dom2	538..895	CDD:212527	78/375 (21%)
		zf-UBP	1007..1069	CDD:460464
HDAC10	NP_114408.3	Histone deacetylase	1..323		162/322 (50%)
		HDAC10	18..354	CDD:212546	167/340 (49%)
		Substrate specificity. /evidence=ECO:0000250|UniProtKB:F1QCV2	21..24		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..387		6/43 (14%)
		Arginase_HDAC	<562..634	CDD:450134	26/93 (28%)