Protein Alignment HDAC6 and HDA05

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001190583.1
• Gene: HDA05 / 836227
• AraportID: AT5G61060
• Length: 664
• Species: Arabidopsis thaliana
• Alignment Length: 664
• Identity: 203/664 - (30%)
• Similarity: 304/664 - (45%)
• Gaps: 155/664 - (23%)

  Fly   533 KVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 597
            ||...||..|..|...:...|||.|.||:.|.:.....|:.::...|....|....:.|.||:.|
plant    26 KVGLIYDETMCKHDTPDGEDHPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDKHLQLVHTKDH 90

  Fly   598 VNTVRRLLGREPK-ELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPP 661
            ||.|:.:..::.. ..:..|...||:||:..:.:.|.||||.|::..:.|..||...|...||||
plant    91 VNLVKSISTKQKDYRRNRIASQLNSIYLNGGSSEAAYLAAGSVVKLAEKVAEGELDCGFAIVRPP 155

  Fly   662 GHHAEQDHPHGFCIFNNVAIAAQYAIR---DFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISL 723
            |||||.|...|||:|||||:||.:.:.   |.|::::||||||||||||||.:|..:|:||:.|:
plant   156 GHHAEADEAMGFCLFNNVAVAASFLLNERPDLGVKKILIVDWDVHHGNGTQKMFWKDPRVLFFSV 220

  Fly   724 HRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVL 788
            ||:|:|.|:|.|.||::::||:|.|.|||:|:||::...||.:|..|:..:::|:|.||||.::.
plant   221 HRHEYGGFYPAGDDGDYNMVGEGPGEGFNINVPWDQGRCGDADYLAAWDHILIPVAREFNPDVIF 285

  Fly   789 VSAGFDAAIGDPLGGCKVTAEGYGMLTH----WLSALASGRIIVCLEGGYNVNSISYAMTMCTKT 849
            :||||||||.||||||.||..||.::..    .|...|.|:|::.||||||::||:.:...|.:.
plant   286 LSAGFDAAINDPLGGCCVTPYGYSVMLKKVGVELMEFAQGKIVLALEGGYNLDSIAKSSLACVQV 350

  Fly   850 LLGDPVPTPQLGATALQKPP-TVAFQSCVESLQQCLQVQRNHWRSL------EFVGRRLPRDPVV 907
            ||.|         ..:|.|| ...|:|....:|...:....:|.||      :.:.::.| .|::
plant   351 LLED---------KQIQGPPEAYPFESTWRVIQAVRKRLCTYWPSLADELSWKLINQKTP-TPII 405

  Fly   908 GENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKPKVKVKTLSDYLAENKEAL 972
                    |.:|      |:.:....|.||.........|.|.|:            |.||.:
plant   406 --------LISS------SDSETEDNAQGLLDQMSKLSIENPQGT------------LLENHQ-- 442

  Fly   973 EQSEMFAVYPLKTCPHLRLLRPEE----------APRSLDSGAECSVCGS--TGENWVCLSCRHV 1025
                   |.|..|.....|.:.:.          .||.|     |.:.|.  .|...||:.
plant   443 -------VEPASTSWRADLAKVDVWYASFGSNMWKPRFL-----CYIQGGQVDGLKKVCVG---- 491

  Fly  1026 ACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYVDHPRLY--------------AYLNPL 1076
                         |:::..|..      :||     ....| ||:              |:.|||
plant   492 -------------SMDKSPPKE------TVW-----ETFPH-RLFFGRESSVGWGVGGVAFTNPL 531

  Fly  1077 HE--DKFQEPMAWTHGCAWR----EDGCYATGPDGRDEDDD------------DDNGA------- 1116
            ..  |:       ||.|.:|    :.....:..:|.:.|.|            |:.|:
plant   532 ANLIDQ-------THMCLYRITLEQFNDVLSQENGLNVDSDSPVFDLAALQLVDNKGSILEAPLN 589

  Fly  1117 ---GSSICLRLERN 1127
               |:.:||..||:
plant   590 SWYGNVVCLGKERD 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	149/371 (40%)
		zf-UBP	1007..1069	CDD:460464	10/63 (16%)
HDA05	NP_001190583.1	Arginase_HDAC	31..388	CDD:450134	148/365 (41%)