Protein Alignment HDAC6 and HDAC11

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_079103.2
• Gene: HDAC11 / 79885
• HGNCID: 19086
• Length: 347
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 89/348 - (25%)
• Similarity: 138/348 - (39%)
• Gaps: 71/348 - (20%)

  Fly   563 IHKMHD-DYG-------LLKQMKQLS------PRAATTDEVCLAHTRAHVNTVR-----RLLGRE 608
            :.|:|. |.|       .||:.|.||      .|.|:.:::.:.|||.::|.::     ..:...
Human    31 LEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEI 95

  Fly   609 PKELHDAAGIYNSVYLHP-RTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHG 672
            |..:.....:.....|.| ||....|:.||.:  ||:       |....||....||...|...|
Human    96 PPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKL--AVE-------RGWAINVGGGFHHCSSDRGGG 151

  Fly   673 FCIFNNVAIAAQYAI-RDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGP 736
            ||.:.::.:|.::.. |..|:.|..|:|.|.|.|||.:..|..:.:|..:.::. .|  .:|.
Human   152 FCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYN-RH--IYPG-- 211

  Fly   737 DGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPL 801
                |...|.|.|. .|.:.|   |..|.||....::.|.....|..|.:|:.:||.|...||.|
Human   212 ----DRFAKQAIRR-KVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 268

  Fly   802 GGCKVTAEGYGMLTHWLSALASGR---IIVCLEGGYN-------VNSISYAMTMCTKTLLGDPVP 856
            ||..::..|.......:..:..||   |::...|||.       .:||   :.:....|:|...|
Human   269 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSI---LNLFGLGLIGPESP 330

  Fly   857 --------TPQLGATALQKPPTV 871
                    ||.|       ||.|
Human   331 SVSAQNSDTPLL-------PPAV 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	89/348 (26%)
		zf-UBP	1007..1069	CDD:460464
HDAC11	NP_079103.2	Histone deacetylase	14..326		81/319 (25%)
		HDAC_classIV	35..319	CDD:212519	79/308 (26%)