DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and HDAC11

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_079103.2	Gene:	HDAC11 / 79885	HGNCID:	19086	Length:	347	Species:	Homo sapiens

Alignment Length:	348	Identity:	89/348 - (25%)
Similarity:	138/348 - (39%)	Gaps:	71/348 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   563 IHKMHD-DYG-------LLKQMKQLS------PRAATTDEVCLAHTRAHVNTVR-----RLLGRE 608
            :.|:|. |.|       .||:.|.||      .|.|:.:::.:.|||.::|.::     ..:...
Human    31 LEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEI 95

  Fly   609 PKELHDAAGIYNSVYLHP-RTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHG 672
            |..:.....:.....|.| ||....|:.||.:  ||:       |....||....||...|...|
Human    96 PPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKL--AVE-------RGWAINVGGGFHHCSSDRGGG 151

  Fly   673 FCIFNNVAIAAQYAI-RDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGP 736
            ||.:.::.:|.::.. |..|:.|..|:|.|.|.|||.:..|..:.:|..:.::. .|  .:|.
Human   152 FCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYN-RH--IYPG-- 211

  Fly   737 DGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPL 801
                |...|.|.|. .|.:.|   |..|.||....::.|.....|..|.:|:.:||.|...||.|
Human   212 ----DRFAKQAIRR-KVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 268

  Fly   802 GGCKVTAEGYGMLTHWLSALASGR---IIVCLEGGYN-------VNSISYAMTMCTKTLLGDPVP 856
            ||..::..|.......:..:..||   |::...|||.       .:||   :.:....|:|...|
Human   269 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSI---LNLFGLGLIGPESP 330

  Fly   857 --------TPQLGATALQKPPTV 871
                    ||.|       ||.|
Human   331 SVSAQNSDTPLL-------PPAV 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	89/348 (26%)
		zf-UBP	1007..1069	CDD:280334
HDAC11	NP_079103.2	Histone deacetylase	14..326		81/319 (25%)
HDAC11	NP_079103.2	HDAC_classIV	35..319	CDD:212519	79/308 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810