DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hdac7a

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_021325750.1	Gene:	hdac7a / 798603	ZFINID:	ZDB-GENE-150129-1	Length:	960	Species:	Danio rerio

Alignment Length:	1008	Identity:	277/1008 - (27%)
Similarity:	399/1008 - (39%)	Gaps:	318/1008 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 SQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSG- 178
            :|||..:.::.          |:|.::.|:.:   .|..:...|.::.:|..::..::....|.
Zfish    76 TQHCSQYSQQQ----------LQRIQQYNMEQ---HLQDQEQAKQQLQQLKHKDKSQQSAVASAL 127

  Fly   179 --------IRDDERMEELSSRYDS--------IYIHPSTFE--------LSLLASGSTI------ 213
                    |...::.:.:..|.:|        .|...:|.:        ||:||..|..
Zfish   128 VKQKLAQVILKKQKQQAVLERTNSNPLSSPSVAYRSENTLKHTGLWSVLLSMLAFCSCFSASEPN 192

  Fly   214 -----ELVDHLVAGKAQNGMAIIRPPG--HHAMKA----------EYNGYCFFNNVALATQHALD 261
                 :|..||...|:........||.  |....|          ..:| |...|.:|.|::...
Zfish   193 LKVKHKLKKHLNTRKSPLTRKESAPPAVKHRTPDALDSSPSSSSTPVSG-CSSPNDSLPTENGAS 256

  Fly   262 ------VHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLH---------ES 311
                  .|:.||:|:.|..:.|                |:|   ::.|..|.:.         |.
Zfish   257 SSSSSLSHEAQRLLLQDGSLSH----------------FTI---QNSSSLPTITLGLPANSKVEG 302

  Fly   312 DYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALE---FQPELIIVSAGYDAALGCP 373
            |..::..|       .|||     .:|.     ..||||:.:|   .||.||:..:|.
Zfish   303 DLSSLKLG-------RVPL-----VSGS-----SPLLLPLGVEEPLMQPVLILEPSGL------- 343

  Fly   374 EGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVET--VP 436
                         :..|||       ||...|...|...|.|           |..||..|  .|
Zfish   344 -------------VHTPLL-------AVPGLGPVPLQFSASG-----------PHKPLSRTRSEP 377

  Fly   437 LPRAE---------LAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKE---------EDL--- 480
            ||::.         |.|...|...:||       |:|.....:|..:..|         ||:
Zfish   378 LPQSPGRLQPHPHLLQQQQHSTHLLHR-------LKQNTHLGKLMQKSSEKPRLRQIPSEDMDSE 435

  Fly   481 --------------------------------HTVL----RHW---------------------- 487
                                            ||::    |.|
Zfish   436 EAGPAAGDAHQGRGRAESQREMENQEEQMNLQHTLILNQSRLWETQKHLQQLRRQTAQMETLAVP 500

  Fly   488 --IGGPP--PMDRYPT--RDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLH- 545
              :||..  |:.|..:  ..|::.||.:.|.      ....||...|.|.|.....||:|||.|
Zfish   501 MMLGGGQHRPLSRTQSSPASTSLTLPEKTLP------LATPAEPPQSQPRFTTGLVYDSQMLKHQ 559

  Fly   546 CNLND-TGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHV-----NTVRRL 604
            |...| :.|||...|||.|.....:.||..|.:.:..|.||.:|:...||..||     |.:.||
Zfish   560 CTCGDNSSHPEHAGRIQSIWSRLQERGLRGQCESIRGRKATLEELQSVHTERHVLLYGTNPLNRL 624

  Fly   605 ----------LGREPKELHDAAGI---YNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGIC 656
                      |.:....:....|:   .::::....|...:.:|||.|.:....|.:||.::|..
Zfish   625 KLDNRKLAGILSQRMFVMLPCGGVGVDNDTIWNEMHTSTASRMAAGSVTELAFRVAKGELKNGFA 689

  Fly   657 NVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYI 721
            .||||||||:..:|.|||.||:|||||:...:.....::||||||||||||||.||.::|.||||
Zfish   690 VVRPPGHHADPSNPMGFCFFNSVAIAAKQLQQKLSASKILIVDWDVHHGNGTQEIFYNDPSVLYI 754

  Fly   722 SLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFN 783
            |||||::|:||| |..|..: ||.|||.|||||:.|.   :..|.|.||..||:.::||||.||:
Zfish   755 SLHRYDNGNFFP-GSGGPAE-VGSGAGEGFNVNVAWTGGLEPPMADAEYLAAFRTVVMPIAQEFS 817

  Fly   784 PQLVLVSAGFDAAIG--DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMC 846
            |.:||||:|||||.|  .||||.||||:.:|.:|..|..||.||:::.||||:::.:|..|...|
Zfish   818 PDVVLVSSGFDAAEGHPSPLGGYKVTAKCFGFMTRQLMTLAGGRVVLALEGGHDLTAICDASEAC 882

  Fly   847 TKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENN 911
            ...|||...|.|:  :|.||.|..    |.|.|||:.||:...:|.||:         |::|
Zfish   883 VSALLGLEEPLPE--STLLQTPSA----SGVLSLQRVLQIHSQYWSSLK---------PLMG--- 929

  Fly   912 NEDFLTASLRHLNISNDDATAAAGGLAGDRPDC 944
                               |.....|...|.||
Zfish   930 -------------------TVGMSFLGAQRKDC 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	78/414 (19%)
		HDAC6-dom2	538..895	CDD:212527	165/381 (43%)
		zf-UBP	1007..1069	CDD:280334
hdac7a	XP_021325750.1	HDAC_classIIa	545..921	CDD:212544	164/383 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820