Protein Alignment HDAC6 and hdac7b

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_017212138.1
• Gene: hdac7b / 792596
• ZFINID: ZDB-GENE-131127-113
• Length: 751
• Species: Danio rerio
• Alignment Length: 667
• Identity: 197/667 - (29%)
• Similarity: 292/667 - (43%)
• Gaps: 155/667 - (23%)

  Fly   360 IIVSAGYDAALGCPEGEMEVT-------PA------------CYPHLLNPLLRLADARVAVVLEG 405
            :|.:..|.|:.|..:..::::       ||            .|||:.
Zfish   135 LIQTTTYSASSGKEDSPLQISIQHPVLWPAYAATAYNPQVFTLYPHIF----------------- 182

  Fly   406 GYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIA-VHRPHWRCLQ--LQQTYD 467
                            ::.|...||:... ||.:::.|.:.:.... :|.|.:..:|  .||.:.
Zfish   183 ----------------TVTGQQWPPMPHR-PLIKSQSAPSYIQQYTHIHTPAYTLVQPMYQQQWP 230

  Fly   468 CVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDT-----AIPLPPEKLTSNAARL--------- 518
            ....|.....|.: :|...|...|..:.|:..|.:     :...|.|.......:|
Zfish   231 QETFQQHTLPEKV-SVGPAWPESPGDLGRFRKRTSEEVRISSQSPLESCNRQGVQLKENLEWRHK 294

  Fly   519 ----QVLRA-------ETKLS----------VPSFKVCYAYDAQMLLH-CNLNDTG---HPEQPS 558
                ||.|.       :|:||          .|:|.....|  :|:.| |:..|:.   |  :..
Zfish   295 IFHQQVSRVHSFPDTFDTRLSSHSASALDMRKPNFTTGLVY--EMMKHRCDCRDSSCGLH--EAD 355

  Fly   559 RIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNSVY 623
            |:..|.....:.||..|.|.|..|:||.:|:...|:.   ..|....|.||.......|   :::
Zfish   356 RVTSIWSRLQECGLRSQCKLLKGRSATVEELLSVHSE---ELVCFFTGPEPYRSQMDIG---TMW 414

  Fly   624 LHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIR 688
            .:||..:...:|.|.|.:....|.||:.|:|...|.||||||.:.......:||:|||||:....
Zfish   415 KNPRNSEALKMAVGSVTELALCVARGDLRNGFAVVTPPGHHASRSQTLDSIVFNSVAIAAKQLQE 479

  Fly   689 DFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNV 753
            ...::::||||||||||:||:.||.::|.|||||||||:.|:||  ...|:...||...|||:||
Zfish   480 QLKVKKILIVDWDVHHGSGTESIFYTDPSVLYISLHRYDDGAFF--NGTGDPSRVGCDVGRGYNV 542

  Fly   754 NIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDP--LGGCKVTAEGYGM 813
            |:.|:   :..|||.||..||:.::||||:||:|.:||||||||||.|.|  |||.:|:.:.:|.
Zfish   543 NVAWSGGLRPPMGDAEYLAAFRTVVMPIAHEFSPNVVLVSAGFDAAEGHPAALGGYRVSPKCFGW 607

  Fly   814 LTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVE 878
            ||..|..||.||:::.|||||.:.|:..|...|...|||:. |.| |....|.:.|..   :.|.
Zfish   608 LTQKLMELAEGRVVLVLEGGYELVSLCDASQACVSALLGNE-PEP-LSEVELLRSPCA---NAVC 667

  Fly   879 SLQQCLQVQRNHWR---------SLEFV-------------------------GRRLPRDPVVGE 909
            ||::.|.||..|||         ||.:|                         .|:||.:||
Zfish   668 SLEKVLHVQSLHWRSVRSMLNTVSLSYVKAERRVSAGSEAALVLSGLNMTVPHRRQLPNEPV--- 729

  Fly   910 NNNEDFLTASLRHLNIS 926
            .::|...|.|......|
Zfish   730 EDDETHSTVSFTRRTFS 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	17/116 (15%)
		HDAC6-dom2	538..895	CDD:212527	148/374 (40%)
		zf-UBP	1007..1069	CDD:460464
hdac7b	XP_017212138.1	Arginase_HDAC	329..680	CDD:450134	145/367 (40%)