DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC6 and Hdac9

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:XP_006515324.1 Gene:Hdac9 / 79221 MGIID:1931221 Length:1100 Species:Mus musculus


Alignment Length:1063 Identity:278/1063 - (26%)
Similarity:409/1063 - (38%) Gaps:292/1063 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 EAKRRARNNML-----KNQGCGSQESVTDI---FQNAVNSKSLVRKPTALIYDESMSQHCCLW-D 122
            |.:|..|...|     |::|.....:.|::   .|..:.|||..:.......:.|:.:|..|| .
Mouse   150 EVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYT 214

  Fly   123 KEHYECPERFTRVLERCRELNLTERCLE--LPSRSATKDEI-LRLHTEEHFERLKETSGIRD--- 181
            ..|:      |.:.:....|:.|....:  ||....:||:. ||....|  ..||..|.::.   
Mouse   215 AAHH------TSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASE--PNLKVRSRLKQKVA 271

  Fly   182 DERMEELSSRYDSIYI---HPSTFE-----LSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHA 238
            :.|...|..|.|...:   ....||     :|..:.||.....::..||......|...||    
Mouse   272 ERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPP---- 332

  Fly   239 MKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSI------- 296
                             |.|...:...|||||     |.........|..|.:...::       
Mouse   333 -----------------TPHPEQLVPQQRILI-----HEDSMNLLSLYTSPSLPNITLGLPAVPS 375

  Fly   297 ----------------HRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQ 345
                            .....|...|..:.|...|..|        :|.:...|.....:.|:.|
Mouse   376 PLNASNSLKDKQKCETQMLRQGVPLPSQYGSSIAASSS--------HVHVAMEGKPTSSHQALLQ 432

  Fly   346 QLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLA-DARVAVVLEGGYCL 409
            .|||...:..|..|:   ||     |.|              |:|...|| ..|::..:.|.:.|
Mouse   433 HLLLKEQMRQQKLLV---AG-----GVP--------------LHPQSPLATKERISPGIRGTHKL 475

  Fly   410 DSLAEGAALTLRSLLGDPCP---PL--VETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTY--- 466
                               |   ||  .::.|||::.|||     :.:.:.|.:.|:.|:.|   
Mouse   476 -------------------PRHRPLNRTQSAPLPQSTLAQ-----LVIQQQHQQFLEKQKQYQQQ 516

  Fly   467 ---------DCVELQD-----RDKEEDLHTVLRHWIGGPPPMDRYPTRDTA-------------- 503
                     ...:|:.     .:.||:|.       |.....||..::|.:              
Mouse   517 IHMNKLLSKSIEQLKQPGSHLEEAEEELQ-------GDQSMEDRAASKDNSARSDSSACVEDTLG 574

  Fly   504 -------------------------------IPLPPEKLTSNAARLQV----------------L 521
                                           :..||...:|.|..|.|                |
Mouse   575 QVGAVKVKEEPVDSDEDAQIQEMECGEQAAFMQQPPLLESSRARSLSVHQTLAAVGTDGLEKHGL 639

  Fly   522 RAETKLS---------------VPSFKVCYAYDAQMLLH---CNLNDTGHPEQPSRIQHIHKMHD 568
            .:.|..|               .||.....|||..||.|   |. :.|.|||...|||.|.....
Mouse   640 LSRTHSSPAASMSPHPAADCPRQPSSATGIAYDPLMLKHQCICG-SSTTHPEHAGRIQSIWSRLQ 703

  Fly   569 DYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTV------------RRLLGREPKELH-------- 613
            :.|||.:.:::..|.|:.:|:.|.|:..|....            |.|||.:.::..        
Mouse   704 ETGLLSKCERIQGRKASLEEIQLVHSEHHSLLYGTSPLDGQKLDPRTLLGDDSRKFFSSLPCGGL 768

  Fly   614 --DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIF 676
              |:..|:|.::    :...|.:|.|.|::....|..||.::|...|||||||||:....|||.|
Mouse   769 GVDSDTIWNELH----SSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFCFF 829

  Fly   677 NNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFD 741
            |:|||.|:|......:.::||||.|||||||||..|.::|.:||||||||:.|:|||  ..|..:
Mouse   830 NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPN 892

  Fly   742 VVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG--DPL 801
            .||.|.|.|:||||.|.   ...|||:||..||:.::||:|.||:|.:|||||||||..|  .||
Mouse   893 EVGVGLGEGYNVNIAWTGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTPPL 957

  Fly   802 GGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQ 866
            ||.||||:.:|.||..|..||:||:.:.||||:::.:|..|...|...|||:. |.| |...||.
Mouse   958 GGYKVTAKCFGHLTKQLMTLANGRVALALEGGHDLTAICDASEACINALLGNE-PGP-LEEDALH 1020

  Fly   867 KPPTVAFQSCVESLQQCLQVQRNHWRSLEFV----GRRLPRDPVVGENNNEDFLTASLRHLNISN 927
            :....   :...|||:.:.:|..:|:|::.|    |..||...:..|...    .::|..|.:..
Mouse  1021 QSVNT---NAAASLQKTIDIQSKYWKSIKMVAAARGGALPASQLQEETET----VSALASLTVDV 1078

  Fly   928 DDATAAAGGLAGDRPDCGDERPS 950
            :...|...|.....|  .:|.|:
Mouse  1079 EQPFAQEDGRTAGEP--MEEEPA 1099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526 74/381 (19%)
HDAC6-dom2 538..895 CDD:212527 155/386 (40%)
zf-UBP 1007..1069 CDD:280334
Hdac9XP_006515324.1 ClassIIa_HDAC9_Gln-rich-N 71..160 CDD:197399 3/9 (33%)
HDAC_classIIa 665..1042 CDD:212544 154/388 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.720

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