DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and Hdac9

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_017449847.1	Gene:	Hdac9 / 687001	RGDID:	1310748	Length:	1094	Species:	Rattus norvegicus

Alignment Length:	1062	Identity:	279/1062 - (26%)
Similarity:	419/1062 - (39%)	Gaps:	296/1062 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LEAKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLW-DKEHYECP 129
            |..|.|.|.:. ::||..:...|....|..:.|||..:.......:.|:.:|..|| ...|:
  Rat   151 LRGKDRGRESK-RHQGAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAAHH--- 211

  Fly   130 ERFTRVLERCRELNLTERCLE--LPSRSATKDEI-LRLHTEEHFERLKETSGIRD---DERMEEL 188
               |.:.:....|:.|....:  ||....|||:. ||....|  ..||..|.::.   :.|...|
  Rat   212 ---TSLDQSSPPLSGTSPSYKYTLPGAQDTKDDFPLRKTASE--PNLKVRSRLKQKVAERRSSPL 271

  Fly   189 SSRYDSIYI---HPSTFE-----LSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNG 245
            ..|.|...:   ....||     :|..:.||.....::..||......|.:.||
  Rat   272 LRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASVLPP----------- 325

  Fly   246 YCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSI-------------- 296
                      |.|...:...|||||     |.........|..|.:...::
  Rat   326 ----------TPHPEQLVPQQRILI-----HEDSMNLLSLYTSPSLPNITLGLPAVPSPLSASNS 375

  Fly   297 ---------HRFEHGSFWPHLHESDYHAIGSG-AGTGYNFNVPLNATGMTNGDYLAIFQQLLLPV 351
                     .....|...|..:       ||| |.:..:.:|.:.  |..|..:.|:.|.|||..
  Rat   376 LKDKQKCETQMLRQGVPLPGQY-------GSGIAASSSHAHVAME--GKPNSSHQALLQHLLLKE 431

  Fly   352 ALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLA-DARVAVVLEGGYCLDSLAEG 415
            .:..|..|:   ||     |.|              |:|...|| ..|::..:.|.:.|
  Rat   432 QMRQQKLLV---AG-----GVP--------------LHPQSPLATKERISPGIRGTHKL------ 468

  Fly   416 AALTLRSLLGDPCP---PL--VETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTY--------- 466
                         |   ||  .::.|||::.|||     :.:.:.|.:.|:.|:.|
  Rat   469 -------------PRHRPLNRTQSAPLPQSTLAQ-----LVIQQQHQQFLEKQKQYQQQIHMNKL 515

  Fly   467 ---DCVELQD-----RDKEEDLHTVLRHWIGGPPPMDRYPTRDT------------------AIP 505
               ...:|:.     .:.||:|.       |.....:|..::|:                  |:.
  Rat   516 LSKSIEQLKQPGSHLEEAEEELQ-------GDQAMEERATSKDSGTGKDSSACVEDTLGQVGAVK 573

  Fly   506 LPPEKLTSNA-ARLQVLR----------------AETK-LSV----------------------- 529
            :..|.:.|:. |::|.:.                :.|: |||
  Rat   574 VKEEPVDSDEDAQMQEMECGEQAAFMQQTPLLESSHTRALSVHQARLAAAGIDGLEKHGLLSRTH 638

  Fly   530 ------------------PSFKVCYAYDAQMLLH---CNLNDTGHPEQPSRIQHIHKMHDDYGLL 573
                              |:.....|||..||.|   |. |.|.|||...|||.|.....:.|||
  Rat   639 SSPAPSMSPHPAADCPRQPASATGIAYDCLMLKHQCICG-NSTTHPEHAGRIQSIWSRLQETGLL 702

  Fly   574 KQMKQLSPRAATTDEVCLAHTRAHVNTV------------RRLLGREPKELH----------DAA 616
            .:.:::..|.|:.:|:.|.|:..|....            |.|||.:.::..          |:.
  Rat   703 NKCERIQGRKASLEEIQLVHSEHHSLLYGTSPLDGQKLDPRTLLGDDSRKFFSSLPCGGLGVDSD 767

  Fly   617 GIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAI 681
            .|:|.::    :...|.:|.|.|::....|..||.::|...|||||||||:....|||.||:|||
  Rat   768 TIWNELH----SSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFCFFNSVAI 828

  Fly   682 AAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKG 746
            .|:|......:.::||||.|||||||||..|.::|.:||||||||:.|:|||  ..|..:.||.|
  Rat   829 TAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGVG 891

  Fly   747 AGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKV 806
            .|.|:||||.|.   ...|||:||..||:.::||:|.||:|.:|||||||||..|  .||||.||
  Rat   892 LGEGYNVNIAWTGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTPPLGGYKV 956

  Fly   807 TAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTV 871
            ||:.:|.||..|..||:||:.:.||||:::.:|..|...|...|||:.       ..:|::  .|
  Rat   957 TAKCFGHLTKQLMTLANGRVALALEGGHDLTAICDASEACINALLGNE-------PGSLEE--DV 1012

  Fly   872 AFQS----CVESLQQCLQVQRNHWRSLEFV----GRRLPRDPVVGENNNEDFLTASLRHLNISND 928
            ..||    ...|||:.:::|..:|:|::.|    |..||...:..|...    .::|..|.:..:
  Rat  1013 LHQSVNTNAAASLQKTIEIQSKYWKSIKMVAVARGCALPASQLQEETET----VSALASLTVDVE 1073

  Fly   929 DATAAAGGLAGDRPDCGDERPS 950
            ...|...|.....|  .:|.|:
  Rat  1074 QPFAQEDGRTAGEP--MEEEPA 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	77/382 (20%)
		HDAC6-dom2	538..895	CDD:212527	155/390 (40%)
		zf-UBP	1007..1069	CDD:280334
Hdac9	XP_017449847.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720