Protein Alignment HDAC6 and Hdac9

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_008762838.2
• Gene: Hdac9 / 687001
• RGDID: 1310748
• Length: 1089
• Species: Rattus norvegicus
• Alignment Length: 1069
• Identity: 279/1069 - (26%)
• Similarity: 421/1069 - (39%)
• Gaps: 303/1069 - (28%)

  Fly    67 EAKRRARNNML-----KNQGCGSQESVTDI---FQNAVNSKSLVRKPTALIYDESMSQHCCLW-D 122
            |.:|..|...|     |::|.....:.|::   .|..:.|||..:.......:.|:.:|..|| .
  Rat   138 EVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYT 202

  Fly   123 KEHYECPERFTRVLERCRELNLTERCLE--LPSRSATKDEI-LRLHTEEHFERLKETSGIRD--- 181
            ..|:      |.:.:....|:.|....:  ||....|||:. ||....|  ..||..|.::.
  Rat   203 AAHH------TSLDQSSPPLSGTSPSYKYTLPGAQDTKDDFPLRKTASE--PNLKVRSRLKQKVA 259

  Fly   182 DERMEELSSRYDSIYI---HPSTFE-----LSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHA 238
            :.|...|..|.|...:   ....||     :|..:.||.....::..||......|.:.||
  Rat   260 ERRSSPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASVLPP---- 320

  Fly   239 MKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSI------- 296
                             |.|...:...|||||     |.........|..|.:...::
  Rat   321 -----------------TPHPEQLVPQQRILI-----HEDSMNLLSLYTSPSLPNITLGLPAVPS 363

  Fly   297 ----------------HRFEHGSFWPHLHESDYHAIGSG-AGTGYNFNVPLNATGMTNGDYLAIF 344
                            .....|...|..:       ||| |.:..:.:|.:.  |..|..:.|:.
  Rat   364 PLSASNSLKDKQKCETQMLRQGVPLPGQY-------GSGIAASSSHAHVAME--GKPNSSHQALL 419

  Fly   345 QQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLA-DARVAVVLEGGYC 408
            |.|||...:..|..|:   ||     |.|              |:|...|| ..|::..:.|.:.
  Rat   420 QHLLLKEQMRQQKLLV---AG-----GVP--------------LHPQSPLATKERISPGIRGTHK 462

  Fly   409 LDSLAEGAALTLRSLLGDPCP---PL--VETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTY-- 466
            |                   |   ||  .::.|||::.|||     :.:.:.|.:.|:.|:.|
  Rat   463 L-------------------PRHRPLNRTQSAPLPQSTLAQ-----LVIQQQHQQFLEKQKQYQQ 503

  Fly   467 ----------DCVELQD-----RDKEEDLHTVLRHWIGGPPPMDRYPTRDT-------------- 502
                      ...:|:.     .:.||:|.       |.....:|..::|:
  Rat   504 QIHMNKLLSKSIEQLKQPGSHLEEAEEELQ-------GDQAMEERATSKDSGTGKDSSACVEDTL 561

  Fly   503 ----AIPLPPEKLTSNA-ARLQVLR----------------AETK-LSV---------------- 529
                |:.:..|.:.|:. |::|.:.                :.|: |||
  Rat   562 GQVGAVKVKEEPVDSDEDAQMQEMECGEQAAFMQQTPLLESSHTRALSVHQARLAAAGIDGLEKH 626

  Fly   530 -------------------------PSFKVCYAYDAQMLLH---CNLNDTGHPEQPSRIQHIHKM 566
                                     |:.....|||..||.|   |. |.|.|||...|||.|...
  Rat   627 GLLSRTHSSPAPSMSPHPAADCPRQPASATGIAYDCLMLKHQCICG-NSTTHPEHAGRIQSIWSR 690

  Fly   567 HDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTV------------RRLLGREPKELH------ 613
            ..:.|||.:.:::..|.|:.:|:.|.|:..|....            |.|||.:.::..
  Rat   691 LQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTSPLDGQKLDPRTLLGDDSRKFFSSLPCG 755

  Fly   614 ----DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFC 674
                |:..|:|.::    :...|.:|.|.|::....|..||.::|...|||||||||:....|||
  Rat   756 GLGVDSDTIWNELH----SSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFC 816

  Fly   675 IFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGN 739
            .||:|||.|:|......:.::||||.|||||||||..|.::|.:||||||||:.|:|||  ..|.
  Rat   817 FFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGA 879

  Fly   740 FDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG--D 799
            .:.||.|.|.|:||||.|.   ...|||:||..||:.::||:|.||:|.:|||||||||..|  .
  Rat   880 PNEVGVGLGEGYNVNIAWTGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTP 944

  Fly   800 PLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATA 864
            ||||.||||:.:|.||..|..||:||:.:.||||:::.:|..|...|...|||:.       ..:
  Rat   945 PLGGYKVTAKCFGHLTKQLMTLANGRVALALEGGHDLTAICDASEACINALLGNE-------PGS 1002

  Fly   865 LQKPPTVAFQS----CVESLQQCLQVQRNHWRSLEFV----GRRLPRDPVVGENNNEDFLTASLR 921
            |::  .|..||    ...|||:.:::|..:|:|::.|    |..||...:..|...    .::|.
  Rat  1003 LEE--DVLHQSVNTNAAASLQKTIEIQSKYWKSIKMVAVARGCALPASQLQEETET----VSALA 1061

  Fly   922 HLNISNDDATAAAGGLAGDRPDCGDERPS 950
            .|.:..:...|...|.....|  .:|.|:
  Rat  1062 SLTVDVEQPFAQEDGRTAGEP--MEEEPA 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	77/382 (20%)
		HDAC6-dom2	538..895	CDD:212527	155/390 (40%)
		zf-UBP	1007..1069	CDD:460464
Hdac9	XP_008762838.2	ClassIIa_HDAC9_Gln-rich-N	59..148	CDD:197399	3/9 (33%)
		HDAC_classIIa	654..1031	CDD:212544	154/392 (39%)