DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hdac1

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001025564.1	Gene:	hdac1 / 594953	XenbaseID:	XB-GENE-479583	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	473	Identity:	120/473 - (25%)
Similarity:	206/473 - (43%)	Gaps:	50/473 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 KVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 597
            ||||.||..:..:  ....|||.:|.||:..|.:..:|||.::|:...|..|:.:|:...|:..:
Frog    10 KVCYYYDGDVGNY--YYGQGHPIKPHRIRMTHNLLLNYGLYRKMEIYRPHKASAEEMTKYHSDDY 72

  Fly   598 VNTVRRLLGREPKELHDAAGIYNSVYLHPRTFD-----CATLAAGLVLQAVDSVLRGESRSGICN 657
            :..:|.:......|.......:|.....| .||     |.....|.|   ..||...:.::.| :
Frog    73 IKFLRSIRPDNMSEYSKQMQRFNVGEDCP-VFDGLFEFCQLSTGGSV---ASSVKLNKQQTDI-S 132

  Fly   658 VRPPG--HHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLY 720
            |...|  |||::....|||..|::.:|....::..  :|||.:|.|:|||:|.:..|.:..:|:.
Frog   133 VNWSGGLHHAKKSEASGFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMT 195

  Fly   721 ISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQ 785
            :|.|:|  |.:||  ..|:...:|.|.|:.:.||.|. :.|:.|..|...|:.::..:...:.|.
Frog   196 VSFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNYPL-RDGIDDESYEAIFKPVMSKVMEMYQPS 255

  Fly   786 LVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTL 850
            .|::..|.|:..||.||...:|.:|:.....::... :..:::...|||.:.:::...|..|...
Frog   256 AVVLQCGADSLSGDRLGCFNLTIKGHAKCVEFIKTF-NLPLLMLGGGGYTIRNVARCWTYETAVA 319

  Fly   851 LGDPVPT------------PQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVG----R 899
            |...:|.            |......  .|..:..|:..|.|::..|....:.|.|....    :
Frog   320 LDSEIPNELPYNDYFEYFGPDFKLHI--SPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQ 382

  Fly   900 RLPRDPV---VGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGD--ERPSGSKPKVK-V 958
            .:|.|.|   .||.:.||    ..:.::|.:.|...|......|..|.|:  .|...|..||| |
Frog   383 AIPEDSVHDDSGEEDEED----PDKRISIRSSDKRIACDEEFSDSEDEGEGGRRNVASFKKVKRV 443

  Fly   959 KTLSDYLAENKEALEQSE 976
            ||..:...|.|:.:::.|
Frog   444 KTEEEKDGEEKKDVKEEE 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	91/375 (24%)
		zf-UBP	1007..1069	CDD:280334
hdac1	NP_001025564.1	HDAC1	4..374	CDD:212534	95/380 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000