DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hdac4

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_005172586.1	Gene:	hdac4 / 568877	ZFINID:	ZDB-GENE-061013-95	Length:	1052	Species:	Danio rerio

Alignment Length:	737	Identity:	235/737 - (31%)
Similarity:	328/737 - (44%)	Gaps:	164/737 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 ATGMTNGDYLAI-FQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLA 395
            |:|..:||.:|: ..|..:|:...|.|     .|...:.|.....|.|...|   |  |.||
Zfish   364 ASGQQDGDRMAVPGLQPGIPITTPFMP-----GAHLPSYLAASSLERESGSA---H--NTLL--- 415

  Fly   396 DARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCP-----------PLVETVPLPRAELAQALLSC 449
              :..|:||.....:||..|       |.|.|..           ||..|...|..:.:|||...
Zfish   416 --QHMVLLEQSAAQNSLVAG-------LSGVPLQSHSIHKLRQHRPLGRTQSAPLPQNSQALQQL 471

  Fly   450 IA---------VHRPHWRCLQLQQTYDCVELQDRDKEEDLH-----TVLRHWIGGPPPMDRYPTR 500
            :.         .|:..::..||..:...|:..:.:::.:.|     ..||...|...|.|..|..
Zfish   472 VVQQQHQQFLEKHKQQFQQQQLHISKMMVKPSEPNRQHESHPEETEEELREHQGLGDPADPLPHG 536

  Fly   501 DTAIPLPPEK----------------------LTSNAARLQVLR------AETKLSV-------- 529
            .|....||::                      |.....|:..||      ....|||
Zfish   537 VTIKQEPPDEQDEDFQQRERQAEEELLFRQQALLLEQQRIHQLRNYQASMEAAGLSVSFPVHRPL 601

  Fly   530 ----------------------PSFKVCYAYDAQMLLH---CNLNDTGHPEQPSRIQHIHKMHDD 569
                                  |.|.....||..|..|   |. |...|||...|||.|.....:
Zfish   602 SRAQSSPASATFPIVVQEPPAKPRFTTGLVYDTLMQKHQCMCG-NSNIHPEHAGRIQSIWSRLQE 665

  Fly   570 YGLLKQMKQLSPRAATTDEVCLAHTRAHV-----NTVRRLLGREPKELH----------DAAGIY 619
            .||..|.:.:..|.||.:|:...|:.|||     |.:|:.|......:.          |:..|:
Zfish   666 TGLRGQCECIRGRKATLEELQTVHSEAHVLLYGTNPLRQKLDSSVTPMFVRLPCGGIGVDSDTIW 730

  Fly   620 NSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQ 684
            |.|:    :...|.||.|.|:..|..|..||.|:|...|||||||||:..|.|||.||:|||||:
Zfish   731 NEVH----SSSAARLAVGSVVDLVFKVASGELRNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAK 791

  Fly   685 YAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGR 749
            ...:...:.::||||||||||||||..|.|:|.|||:|||||:.|:|||  ..|..|.||.|.|.
Zfish   792 LLQQRLNVSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFP--GSGAPDEVGIGPGV 854

  Fly   750 GFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKVTAE 809
            |||||:.:.   :..|||.:|..||:.::||||.||:|.:||||:||||..|  .||||.|:||:
Zfish   855 GFNVNMAFTGGLEPPMGDADYLAAFRSVVMPIANEFSPDVVLVSSGFDAVEGHPPPLGGYKLTAK 919

  Fly   810 GYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLG---DPVPTPQLGATALQKPPTV 871
            .:|.||..|..||.||:::.||||:::.:|..|...|...|||   ||:|     ...||:.|..
Zfish   920 CFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELDPIP-----EDILQQRPNA 979

  Fly   872 AFQSCVESLQQCLQVQRNHWRSLE----FVGRRLPRDPVVGENNNEDFLTASLRHLNISNDDATA 932
               :.::|:::.|:||..:||||:    .:|..| |:....||...:.:|| :..|:::|..
Zfish   980 ---NAIQSMEKVLEVQSKYWRSLQRSVSTLGYSL-REAQRCENEEAETVTA-MASLSVANKH--- 1036

  Fly   933 AAGGLAGDRPDCGDERPSGSKP 954
                 .|.||   :|.|...:|
Zfish  1037 -----MGKRP---EEEPMEEEP 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	35/145 (24%)
		HDAC6-dom2	538..895	CDD:212527	162/382 (42%)
		zf-UBP	1007..1069	CDD:280334
hdac4	XP_005172586.1	ClassIIa_HDAC4_Gln-rich-N	62..151	CDD:197398
		PKK	68..187	CDD:289257
		Arginase_HDAC	623..1025	CDD:302587	170/417 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820