DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and hdac6

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_009302026.1	Gene:	hdac6 / 565482	ZFINID:	ZDB-GENE-030131-3232	Length:	1081	Species:	Danio rerio

Alignment Length:	1145	Identity:	467/1145 - (40%)
Similarity:	629/1145 - (54%)	Gaps:	168/1145 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AAGGTGSSSGSISGGFNAADPRKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQNA-VNS 98
            |...|..|||...|    ....|:||.|  |.||:|:.|.:..|     ::|.:::..||. |..
Zfish     3 AVPDTKGSSGPPRG----TPETKNNKKN--LQEARRKGRMDRSK-----AEEEMSNELQNLDVQG 56

  Fly    99 KSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILR 163
            ||.. ..|.|:|.::.::..||||..|.|||.|.:.|:|......|..||:::.:|:.|:||:|.
Zfish    57 KSKA-TGTGLVYVDAFTRFHCLWDASHPECPARVSTVMEMLETEGLLGRCVQVEARAVTEDELLL 120

  Fly   164 LHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGM 228
            :||:|:.|.:|.|..:.::| ::.|:.:|||:|:||..|..:.|:.||.::|||.::..:.:||.
Zfish   121 VHTKEYVELMKSTQNMTEEE-LKTLAEKYDSVYLHPGFFSSACLSVGSVLQLVDKVMTSQLRNGF 184

  Fly   229 AIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVY 293
            :|.|||||||...:.||:|.|||:|:|.::|...|::||:||:|:|||||||.|..|..||.|:|
Zfish   185 SINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLY 249

  Fly   294 FSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPE 358
            ||:||:|.|||||||.|||..::|||||.|||.|:|.|..||.:|||:..|||||||||.||||:
Zfish   250 FSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQ 314

  Fly   359 LIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSL 423
            |::|:||:||.:|.|:|.|:|:|.|:..|.:.|..:|..|:.:.|||||.|.|.|||...::|||
Zfish   315 LVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSL 379

  Fly   424 LGDPCPPLVETVPLPRAELAQALLS---CIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLR 485
            ||||||.|    |...|....||.|   .|:...|.|:.|   ||::
Zfish   380 LGDPCPHL----PSSGAPCESALKSISKTISDLYPFWKSL---QTFE------------------ 419

  Fly   486 HWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLND 550
               |||        .....|||..           :.||.|:|.|...:  .||.:|:||.|:.|
Zfish   420 ---GGP--------LSEVSPLPAP-----------VCAEVKVSSPITGL--VYDQRMMLHHNMWD 460

  Fly   551 TGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDA 615
            :.|||.|.||..|...|::..||.:..::..|.||.:|:.|.|:..|::.::.....:|::|:..
Zfish   461 SHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRL 525

  Fly   616 AGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVA 680
            ...|||:::...::.||.||||....:..::|.|:.|:.:..|||||||||:|...|||.||..|
Zfish   526 GDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAA 590

  Fly   681 IAAQYA--IRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVV 743
            :.|:||  |....| ||||||||||||||||||||.:..||||||||||.|:|||...|.|:|.|
Zfish   591 LTARYAQSITRESL-RVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKV 654

  Fly   744 GKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTA 808
            |.|.|||:|||||||...|||.||..||..|:||||.||.|:|||||||||||.||||||.:||.
Zfish   655 GLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTP 719

  Fly   809 EGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAF 873
            |||..|||.|.:||:||:::.||||||:.|||.:|:|||..||||..|:.. ..|.|:...||
Zfish   720 EGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLD-HLTPLKTSATV-- 781

  Fly   874 QSCVESLQQCLQVQRNHWRSLEF-----------------------VGRRLPRDPVVGENNNE-- 913
                 |:...|:.....|.||..                       .|::.||.....::..:
Zfish   782 -----SINNVLRAHAPFWSSLRVNIPESLRLSLPSPKPKGKCTPGGKGKKSPRQSTPSQSPGQAT 841

  Fly   914 --------DFLTASLRHLNISNDDA------TAAAGGL--------------------------- 937
                    |.|||.|..||::...:      :.|.||.
Zfish   842 HRPDQSGFDELTADLLSLNLNTSTSSNTSPESVAVGGARRKVKPNTHRVSAGLESESPLKLNPEK 906

  Fly   938 --AGDRPDCGDERP--SGSKPKV-----KVKTLSDYLAE---------------NKEALEQSEMF 978
              |||..|...|.|  |.|:|.|     .||.....:.|               ..:|.:...|:
Zfish   907 AGAGDDTDVKAETPNRSISEPVVTCDSSAVKDQESLVLEAAGGNTVQSVLERVFGAQATDVDTMY 971

  Fly   979 AVYPLKTCPHLRLLRPEEAPRSLDSGAECSVCGSTGENWVCLSCRHVACGRYVNAHMEQHSVEEQ 1043
            .|.||..||||..:||..| ..:|....|..||...|||:||.|..|.||||||.||..|..|..
Zfish   972 VVDPLPWCPHLESVRPVPA-GGIDVFQPCEECGGEAENWICLFCYKVLCGRYVNQHMVTHGQESG 1035

  Fly  1044 HPLAMSTADLSVWCYACSAYVDHPRLYAYLNPLHEDKFQE 1083
            ||:.:|.||||||||||.:||.:..|:...|..|..||.|
Zfish  1036 HPVVLSFADLSVWCYACESYVHNKVLHEAKNAAHLVKFGE 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	166/340 (49%)
		HDAC6-dom2	538..895	CDD:212527	180/358 (50%)
		zf-UBP	1007..1069	CDD:280334	35/61 (57%)
hdac6	XP_009302026.1	HDAC6-dom1	76..412	CDD:212545	166/340 (49%)
		HDAC6-dom2	448..798	CDD:212527	180/358 (50%)
		zf-UBP	999..1061	CDD:280334	35/61 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593968
Domainoid	1	1.000	328	1.000	Domainoid score	I1147
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31353
Inparanoid	1	1.050	789	1.000	Inparanoid score	I497
OMA	1	1.010	-	-		QHG45835
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	1	1.000	-	-		oto39787
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X2174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800