DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC6 and Hdac7

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:XP_036015418.1 Gene:Hdac7 / 56233 MGIID:1891835 Length:977 Species:Mus musculus


Alignment Length:1129 Identity:279/1129 - (24%)
Similarity:408/1129 - (36%) Gaps:385/1129 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSPPIVTRRSAQQAKIQTRAMASKSKTGTTGAATAAG---------------------------- 37
            |.||:...:..||.: :.|.:.:|.|:..:..|::..                            
Mouse    75 MDPPMPELQGGQQEQ-ELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPSSPSIP 138

  Fly    38 -------GTGSSSGSISGGFNAADP------------RKS-NKPNAAL----LEAKRRARNNMLK 78
                   .|..::.|:...|....|            ||: ::||..|    .::..|.:|.:|:
Mouse   139 YRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLR 203

  Fly    79 NQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELN 143
            .:..               ..||.|:|...:.|.|               |...:.....|...|
Mouse   204 KESA---------------PPSLRRRPAETLGDSS---------------PSSSSTPASGCSSPN 238

  Fly   144 LTERCLELPSRSATKDEIL--RLHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSL 206
            .:|..   |:.:...:.:|  ||       ||:|||                   :.|.......
Mouse   239 DSEHG---PNPALGSEALLGQRL-------RLQETS-------------------LAPFALPTVS 274

  Fly   207 LASGSTIELVDHLVAGKAQNGMAIIRPPG------------HHAMKAEYNGYCFFNNVALATQHA 259
            |....|:.|.....|...:...:.:.|.|            ||.::.|..|       .|.:   
Mouse   275 LLPAITLGLPAPARADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGG-------TLPS--- 329

  Fly   260 LDVHKLQRILIIDYDVHH-------GQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIG 317
                :||.||::|..|.|       |.|...|.:..|.:....:                     
Mouse   330 ----RLQPILLLDPSVSHAPLWTVPGLGPLPFHFAQPLLTTERL--------------------- 369

  Fly   318 SGAGTGYNFNVPLNAT-------GMTNGDYLAIFQ----------QLLLPVALEFQ--------P 357
            ||:|    .:.|||.|       ..|....||..|          ||:.|.....|        |
Mouse   370 SGSG----LHRPLNRTRSEPLPPSATASPLLAPLQPRQDRLKPHVQLIKPAISPPQRPAKPSEKP 430

  Fly   358 ELIIVSAGYD--------------------AALGCPEG--------EMEVTPACYPHLLNPLLRL 394
            .|..:.:..|                    :..|.|||        ..:|.|....||..     
Mouse   431 RLRQIPSAEDLETDGGGVGPMANDGLEHRESGRGPPEGRGSISLQQHQQVPPWEQQHLAG----- 490

  Fly   395 ADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPHWRC 459
                            .|::|:.       ||       :|.:|.|::.         |||    
Mouse   491 ----------------RLSQGSP-------GD-------SVLIPLAQVG---------HRP---- 512

  Fly   460 LQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTS--NAARLQVLR 522
                                                  .:|..:.|..|..|.|  ...:.|||.
Mouse   513 --------------------------------------LSRTQSSPAAPVSLLSPEPTCQTQVLN 539

  Fly   523 AETKLSVPSFKVCYAYDAQMLLH-CNLNDTG-HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAAT 585
            :.   ..|:..:  .||:.||.| |:..|.. |||...|||.|.....:.||..|.:.|..|.|:
Mouse   540 SS---ETPATGL--VYDSVMLKHQCSCGDNSKHPEHAGRIQSIWSRLQERGLRSQCECLRGRKAS 599

  Fly   586 TDEVCLAHTRAHV-----NTVRR----------LLGREPKELHDAAGI---YNSVYLHPRTFDCA 632
            .:|:...|:..||     |.:.|          ||.:....:....|:   .::::....:.:.|
Mouse   600 LEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAA 664

  Fly   633 TLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLI 697
            ..|||.|......|...|.::|...||||||||:.....|||.||:||||.:...:.....::||
Mouse   665 RWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQHGKASKILI 729

  Fly   698 VDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---K 759
            ||||||||||||..|..:|.||||||||::.|:|||  ..|..|.||.|:|.|||||:.|.   .
Mouse   730 VDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGTGSGEGFNVNVAWAGGLD 792

  Fly   760 KGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGD--PLGGCKVTAEGYGMLTHWLSALA 822
            ..|||.||..||:.::||||.||.|.|||||||||||.|.  ||||..|:|:.:|.:|..|..||
Mouse   793 PPMGDPEYLAAFRIVVMPIAREFAPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLA 857

  Fly   823 SGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQVQ 887
            .|.:::.||||:::.:|..|...|...|||:.| .|....:..|||..    |.:.||:..::|.
Mouse   858 GGAVVLALEGGHDLTAICDASEACVAALLGNKV-DPLSEESWKQKPNL----SAIRSLEAVVRVH 917

  Fly   888 RNHWRSLEFVG----RRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDER 948
            |.:|..::.:.    ..|||.|  |.:...:.:||.          |:.:.|.||.|||      
Mouse   918 RKYWGCMQRLASCPDSWLPRVP--GADAEVEAVTAL----------ASLSVGILAEDRP------ 964

  Fly   949 PSGSKPKVKVKTLSDYLAENKEAL 972
                         |:.|.|.:|.:
Mouse   965 -------------SERLVEEEEPM 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526 72/411 (18%)
HDAC6-dom2 538..895 CDD:212527 153/381 (40%)
zf-UBP 1007..1069 CDD:280334
Hdac7XP_036015418.1 PHA03247 <124..527 CDD:223021 93/586 (16%)
HDAC7 546..921 CDD:212532 152/383 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2991
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
65.710

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