DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and usp30

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_005165213.1	Gene:	usp30 / 559099	ZFINID:	ZDB-GENE-060526-335	Length:	501	Species:	Danio rerio

Alignment Length:	189	Identity:	40/189 - (21%)
Similarity:	71/189 - (37%)	Gaps:	46/189 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 EKLTS-NAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGL 572
            |..|| |:|..:....||:||....        |:|...:.:|.|..:          :.|..||
Zfish    93 EDFTSQNSADRERTERETQLSRSLM--------QLLKALSSHDPGEDD----------VLDAGGL 139

  Fly   573 LKQMKQLSPRAATTDEVCLAHTRAHV--NTVRRLLGREPKELH--DAAGIYNSVYLHPRTFDCAT 633
            |:.::......::.:|.. ||...||  :::.....|:|:..|  |...:..||....:...|
Zfish   140 LEALRLYRWHISSFEEQD-AHELFHVLTSSLEEEQERQPRVAHLFDMQTLEKSVESKEKNISC-- 201

  Fly   634 LAAGLVLQAVDSVLRGESRSGICNVRPPGH----------HAEQDHPHGFCIFNNVAIA 682
             .:|..|..:.|:.|         .|.|.|          ..||..|..:..|::::::
Zfish   202 -RSGGPLHPIPSLWR---------TRHPFHGRLTSYMACKRCEQQSPVHYDSFDSLSLS 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	31/159 (19%)
		zf-UBP	1007..1069	CDD:280334
usp30	XP_005165213.1	Peptidase_C19	57..>171	CDD:271592	22/96 (23%)
		Peptidase_C19F	65..490	CDD:239127	40/189 (21%)
		UCH	65..489	CDD:278850	40/189 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900