Protein Alignment HDAC6 and hdac5

DIOPT Version :9

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_685659.5
• Gene: hdac5 / 557486
• ZFINID: ZDB-GENE-121219-3
• Length: 1128
• Species: Danio rerio
• Alignment Length: 1146
• Identity: 289/1146 - (25%)
• Similarity: 434/1146 - (37%)
• Gaps: 335/1146 - (29%)

  Fly    30 TGAATAAGGTGSSSGSISGGFN-AADPRKS--NKPNAALLEAKRRARNNMLKNQGCGSQESVTDI 91
            :|..:..||.|...|...|..: ..|||.|  :..:.:|.|.:.:....:||.|    ||
Zfish    59 SGMQSPVGGGGDQGGGSGGPVDLRTDPRLSALSAVDPSLREKQLQHELLLLKQQ----QE----- 114

  Fly    92 FQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSA 156
                      ::|  .|::.|...||                .||.|..|:.|.|...:
Zfish   115 ----------LQK--QLLFAEFQKQH----------------EVLTRQHEVQLQEHLKQ------ 145

  Fly   157 TKDEILRLHTEEHFERLKETSGIRDDE----RMEELSSRYDSIYIHPSTFELSLLAS---GSTIE 214
             :.|||....::..|:.::....|.:|    |:|:               :|.:|.:   |....
Zfish   146 -QQEILAAKRQQELEQKRKLEQQRHEEMEKQRLEQ---------------QLIMLRNKEKGKESA 194

  Fly   215 LVDHLVAGKAQNGMAIIRPPG---------------HHA-----------------------MKA 241
            :....|..|.|..:...:.||               ||.                       :..
Zfish   195 IASTEVKLKLQEFLLSKKEPGPGGLNHSFPQKCWGAHHTSLEQSSPPQSNTPGTPPSYKLPPLLG 259

  Fly   242 EYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWP 306
            .|.|...|.....|::..|.|...     :...|...:.:......|..|    |..|:..:...
Zfish   260 SYEGKDDFPLRKTASEPNLKVRSR-----LKQKVAERRSSPLLRRKDGTV----ISTFKKRAIEI 315

  Fly   307 HLHESDYHAIGSGAGTGYNFNVPLNATGMT------NGDYLAIFQQLLL------PVALEFQPEL 359
            .:......|.|||..:..:.|..:...|.:      :.:.|....|.|.      |::|...|.|
Zfish   316 SVSSMCSSAPGSGPSSPNSSNCAIAENGSSGSVPNIHAEQLRSLHQSLTGDGAPSPLSLYTSPSL 380

  Fly   360 IIVSAGY--DAALGCP-------EGEMEV-------------------TPACY----PH------ 386
            ..:|.|.  :|.:..|       |.|.:.                   .|.|.    ||
Zfish   381 PNISLGLPANAHITAPQKLSAQQEAERQTIQSLRQGGALTGKFISTSSLPTCLSTGAPHDPEPPA 445

  Fly   387 ----------LLNPLLRLADAR-----VAVVLEGGYCLDSLAEGAALTLRSLLGDPCP---PLVE 433
                      ||..:|.|..||     :||.:   |....|..|..::......:..|   ||..
Zfish   446 ASNSHSSHSSLLQHVLLLEQARQQSALLAVPM---YGQSPLVTGERVSNNMRTVNKLPRHRPLSR 507

  Fly   434 TVPLPRAELAQALLSCIAVHRPHWRCLQLQQTY----------------------------DCVE 470
            |...|..:..|| |..:.:.:.|...|:.|:.|                            :..|
Zfish   508 TQSAPLPQTPQA-LQHLVMQQQHQHFLEKQKHYQLNKILSKGTDLPRQPPTHPEETEEELTETAE 571

  Fly   471 LQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTS---------------------- 513
            :||...|...|  :|..:......:..|..:..:||..|...|
Zfish   572 MQDERGEGPDH--VREGLQKDSSGETTPPSERIVPLKGESTESDLEEEDDEDEAVELRECDEDAP 634

  Fly   514 --------NAARLQVLRAETKLS--------------------------VP---SFKVCYAYDAQ 541
                    :..:|.|.:|...::                          ||   .|.....||..
Zfish   635 YGQYLDQQHVQQLNVFQASLSITGMPHRPLGRAQSSPVTSSLKGTTLNEVPIKHLFTTGLVYDTF 699

  Fly   542 MLLH-CNLNDTG-HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTV--- 601
            ||.| |...:|. |||...|||.:.....:.|||.:.:::..|.||.||:...|:..|....
Zfish   700 MLKHQCMCGNTNIHPEHAGRIQSVWSRLQETGLLGRCERIRGRKATLDEIQTVHSEYHTLLYGTS 764

  Fly   602 ---------RRLLGREPKELH----------DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVL 647
                     ::|||...::::          |:..::|.::    :.....:|.|.|::....|.
Zfish   765 PLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMH----SSGAVRMAVGCVIELAFKVA 825

  Fly   648 RGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIF 712
            .||.::|...|||||||||:....|||.||:|||.|:...:..|:.::||:|||:|||||||..|
Zfish   826 AGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLGVGKILIIDWDIHHGNGTQQAF 890

  Fly   713 ESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQL 774
            .::|.|||||||||:.|:|||  ..|..:.||.|.|.||||||.|.   :..|||:||..||:.:
Zfish   891 YNDPNVLYISLHRYDDGNFFP--GSGAPEEVGVGPGEGFNVNIAWTGGVEPPMGDVEYLTAFRTV 953

  Fly   775 IMPIAYEFNPQLVLVSAGFDAAIG--DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVN 837
            :||||.||:|.:|||||||||..|  .||||..|||:.:|.||..|..||.||:::.||||:::.
Zfish   954 VMPIANEFSPDVVLVSAGFDAVEGHQSPLGGYNVTAKCFGHLTKQLMKLAGGRVVLALEGGHDLT 1018

  Fly   838 SISYAMTMCTKTLLGDPV-PTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRL 901
            :|..|...|.:.||||.: |.|   .|.||:.|.   .....||::.:::|..||.||:    ||
Zfish  1019 AICDASESCVEALLGDELNPLP---LTVLQQKPC---PKATASLERVIEIQSKHWTSLQ----RL 1073

  Fly   902 PRDPVVG---------ENNNEDFLTASLRHLNISNDDATAA 933
            .  |.||         |.:..|.||| :..|.:.|:..|.:
Zfish  1074 A--PTVGQSLLDAQRREKDEADTLTA-MASLTVDNEQQTTS 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	77/450 (17%)
		HDAC6-dom2	538..895	CDD:212527	155/386 (40%)
		zf-UBP	1007..1069	CDD:280334
hdac5	XP_685659.5	ClassIIa_HDAC5_Gln-rich-N	94..181	CDD:197400	26/145 (18%)
		HDAC5	688..1107	CDD:212531	169/437 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750