DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and HDAC7

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_011536780.1	Gene:	HDAC7 / 51564	HGNCID:	14067	Length:	1035	Species:	Homo sapiens

Alignment Length:	793	Identity:	236/793 - (29%)
Similarity:	324/793 - (40%)	Gaps:	230/793 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 GDYLAIFQQLLLPVALEFQPELIIVSAGYDA-------------------ALGCPEGEMEVTPAC 383
            |..|.:.:..:.|.||.....|..::.|..|                   .||.|.     ||..
Human   313 GQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPH-----TPLF 372

  Fly   384 YPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPC---PPLVETV----PLPRAE 441
            .||.|.|             |.|..|.|..:..      ||.||.   .||: ||    ||| ..
Human   373 LPHGLEP-------------EAGGTLPSRLQPI------LLLDPSGSHAPLL-TVPGLGPLP-FH 416

  Fly   442 LAQALLSC--IAVHRPHW-------------------------RCLQLQQTYDCVELQDRDKE-- 477
            .||:|::.  ::....||                         |..||:.....::...:..|
Human   417 FAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKP 481

  Fly   478 --------EDL----------------HTVLRHW---IGGPPPMDRYP----------------- 498
                    |||                |..|.|.   ..||.|:.::|
Human   482 RLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRG 546

  Fly   499 -TRDTAI-----------------PLPPEKLTS--NAARLQVL-RAETKLSVPSFKVCYAYDAQM 542
             |.||.:                 |..|..|::  .|::.:|| .:||......|.....||:.|
Human   547 STGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVM 611

  Fly   543 LLH-CNLNDTG-HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHV-----NT 600
            |.| |:..|.. |||...|||.|.....:.||..|.:.|..|.|:.:|:...|:..||     |.
Human   612 LKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP 676

  Fly   601 VRR-------LLGREPKELH----------DAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLR 648
            :.|       |.|...:.:.          |...|:|.::    :.:.|..|||.|......|..
Human   677 LSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELH----SSNAARWAAGSVTDLAFKVAS 737

  Fly   649 GESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFE 713
            .|.::|...||||||||:.....|||.||:||||.:...:.....::||||||||||||||..|.
Human   738 RELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFY 802

  Fly   714 SNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLI 775
            .:|.||||||||::.|:|||  ..|..|.||.|:|.|||||:.|.   ...|||.||..||:.::
Human   803 QDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVV 865

  Fly   776 MPIAYEFNPQLVLVSAGFDAAIGD--PLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNS 838
            ||||.||:|.|||||||||||.|.  ||||..|:|:.:|.:|..|..||.|.:::.||||:::.:
Human   866 MPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTA 930

  Fly   839 ISYAMTMCTKTLLGDPV-PTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRL- 901
            |..|...|...|||:.| |..:.|..  |||..    :.:.||:..::|...:|..::    ||
Human   931 ICDASEACVAALLGNRVDPLSEEGWK--QKPNL----NAIRSLEAVIRVHSKYWGCMQ----RLA 985

  Fly   902 -------PRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSKPKVKVK 959
                   ||.|  |.:..|.....:|..|::         |.||.|||
Human   986 SCPDSWVPRVP--GADKEEVEAVTALASLSV---------GILAEDRP----------------- 1022

  Fly   960 TLSDYLAENKEAL 972
              |:.|.|.:|.:
Human  1023 --SEQLVEEEEPM 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	35/146 (24%)
		HDAC6-dom2	538..895	CDD:212527	154/386 (40%)
		zf-UBP	1007..1069	CDD:280334
HDAC7	XP_011536780.1	HDAC7	601..978	CDD:212532	154/388 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720