Protein Alignment HDAC6 and Hdac1

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_032254.1
• Gene: Hdac1 / 433759
• MGIID: 108086
• Length: 482
• Species: Mus musculus
• Alignment Length: 468
• Identity: 115/468 - (24%)
• Similarity: 200/468 - (42%)
• Gaps: 40/468 - (8%)

  Fly   533 KVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 597
            ||||.||..:..:  ....|||.:|.||:..|.:..:|||.::|:...|..|..:|:...|:..:
Mouse    10 KVCYYYDGDVGNY--YYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDY 72

  Fly   598 VNTVRRLLGREPKELHDAAGIYNSVYLHPRTFD-----CATLAAGLVLQAVDSVLRGESRSGICN 657
            :..:|.:......|.......:|.....| .||     |.....|.|..||.  |..:......|
Mouse    73 IKFLRSIRPDNMSEYSKQMQRFNVGEDCP-VFDGLFEFCQLSTGGSVASAVK--LNKQQTDIAVN 134

  Fly   658 VRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYIS 722
            .....|||::....|||..|::.:|....::..  :|||.:|.|:|||:|.:..|.:..:|:.:|
Mouse   135 WAGGLHHAKKSEASGFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVS 197

  Fly   723 LHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLV 787
            .|:|  |.:||  ..|:...:|.|.|:.:.||.|. :.|:.|..|...|:.::..:...|.|..|
Mouse   198 FHKY--GEYFP--GTGDLRDIGAGKGKYYAVNYPL-RDGIDDESYEAIFKPVMSKVMEMFQPSAV 257

  Fly   788 LVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLG 852
            ::..|.|:..||.||...:|.:|:.....::.:. :..:::...|||.:.:::...|..|...|.
Mouse   258 VLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSF-NLPMLMLGGGGYTIRNVARCWTYETAVALD 321

  Fly   853 DPVPT------------PQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVG----RRL 901
            ..:|.            |......  .|..:..|:..|.|::..|....:.|.|....    :.:
Mouse   322 TEIPNELPYNDYFEYFGPDFKLHI--SPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAI 384

  Fly   902 PRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGD---ERPSGSKPKVKVKTLSD 963
            |.|.:..|:.:||......| ::|.:.|...|......|..:.|:   :..|..|...:|||..:
Mouse   385 PEDAIPEESGDEDEEDPDKR-ISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDE 448

  Fly   964 YLAENKEALEQSE 976
            ...:.:|..|.:|
Mouse   449 KEKDPEEKKEVTE 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	91/373 (24%)
		zf-UBP	1007..1069	CDD:460464
Hdac1	NP_032254.1	HDAC1	4..374	CDD:212534	95/378 (25%)
		Histone deacetylase	9..321		86/323 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..482		17/73 (23%)