DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and hdac11

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_021335266.1	Gene:	hdac11 / 431718	ZFINID:	ZDB-GENE-040704-7	Length:	375	Species:	Danio rerio

Alignment Length:	321	Identity:	74/321 - (23%)
Similarity:	122/321 - (38%)	Gaps:	69/321 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 PEQPSRIQHIHKMHD-DYG----LLKQMKQ---------LSPRAATTDEVCLAHTRAHVNTVRRL 604
            ||.......:.|:|. |.|    :::.:|:         :..|.|:..::.:.||..::|.::..
Zfish    33 PEYNITFMGLEKLHPFDAGKWGKVIRFLKEEQFITDEIIVLAREASEADLLVVHTARYLNRLKNA 97

  Fly   605 L---GRE-----------PKELHDAAGIYNSVYLHP-RTFDCATLAAGLVLQAVDSVLRGESRSG 654
            :   .||           |..|.....:.....|.| ||....|:.||.:  |:|       |..
Zfish    98 ILEGSREWSLVVATITEIPPLLFLPNFLVQRKVLRPLRTQTGGTIMAGKL--AID-------RGW 153

  Fly   655 ICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAI-RDFGLERVLIVDWDVHHGNGTQHIFESNPKV 718
            ..||....||...|...|||.:.::.:|.::.. |..|:....|:|.|.|.|||.:..|..:.:|
Zfish   154 AINVGGGFHHCSSDKGGGFCAYADITLAIKFLFERVEGVASATIIDLDAHQGNGHERDFLEDRRV 218

  Fly   719 LYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGF-------NVNIPWNKKGMGDLEYALAFQQLIM 776
            ..:.::. .|  .:|              |.|:       .|.:.|   |..|.||.........
Zfish   219 YIMDVYN-RH--IYP--------------GDGYAKRAIKRKVELDW---GTEDSEYLQKVDLHSE 263

  Fly   777 PIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGR---IIVCLEGGY 834
            ....|..|.:::.:||.|...||||||..::.:|.......:...|..|   |::...|||
Zfish   264 GALNEARPDIIIYNAGTDILDGDPLGGLAISPQGIIKRDEIIFRAARRRGIPILMVTSGGY 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	74/321 (23%)
		zf-UBP	1007..1069	CDD:280334
hdac11	XP_021335266.1	HDAC_classIV	46..339	CDD:212519	71/308 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910