DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC6 and hdac3

DIOPT Version :10

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:NP_957284.1 Gene:hdac3 / 393965 ZFINID:ZDB-GENE-040426-847 Length:428 Species:Danio rerio


Alignment Length:446 Identity:105/446 - (23%)
Similarity:185/446 - (41%) Gaps:73/446 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   533 KVCYAYDAQMLLHCNLN-DTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRA 596
            :..|.||..:   .|.: ..|||.:|.|:...|.:...|||.|:|....|..|:..::|..|:..
Zfish     4 RTAYFYDPDV---GNFHYGAGHPMKPHRLSLTHSLVLHYGLYKKMMVFKPYKASQHDMCRFHSED 65

  Fly   597 HVNTVRRLLGREPKELHDAAGIYN---SVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNV 658
            :::.::::.....:....:...:|   ...:.|..|:..:...|..||....:     ...||::
Zfish    66 YIDFLQKVSPNNMQGFTKSLNTFNVGGDCPVFPGLFEFCSRYTGASLQGATQL-----NHKICDI 125

  Fly   659 R---PPG-HHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVL 719
            .   ..| |||::....|||..|::.|:....::..  .|||.:|.|:|||:|.|..|....:|:
Zfish   126 AINWAGGLHHAKKFEASGFCYVNDIVISILELLKYH--PRVLYIDIDIHHGDGVQEAFYLTDRVM 188

  Fly   720 YISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNP 784
            .:|.|:|  |::|..| .|:...||..:||.:.:|:|. :.|:.|..|...||.:|..:...:.|
Zfish   189 TVSFHKY--GNYFFPG-TGDMYEVGAESGRYYCLNVPL-RDGIDDQSYRQLFQPVIKQVVDFYQP 249

  Fly   785 QLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKT 849
            ..:::..|.|:...|.||...::..|:|....::..... .::|...|||.|.:::...|..|..
Zfish   250 TCIVLQCGADSLGCDRLGCFNLSIRGHGECVEFVKGFKI-PLLVLGGGGYTVRNVARCWTFETSL 313

  Fly   850 L----LGDPVPTP---QLGATALQKPPTVAF----QSCVESLQQCLQV------QRNHWRSLEFV 897
            |    :.|.:|..   :..|......|.|:.    |:..:.|:|..|.      ..||..|::. 
Zfish   314 LVEESISDELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLEQIRQTVFENLKMLNHAPSVQI- 377

  Fly   898 GRRLPRDPVVGENNNEDFLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSK 953
             |.:|.|.                               |:.:|||..|....||:
Zfish   378 -RDVPSDL-------------------------------LSYERPDEADPEERGSE 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526
HDAC6-dom2 538..895 CDD:212527 94/381 (25%)
zf-UBP 1007..1069 CDD:460464
hdac3NP_957284.1 HDAC3 3..383 CDD:212529 97/395 (25%)
Histone deacetylase 3..316 83/326 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..428 9/52 (17%)
Blue background indicates that the domain is not in the aligned region.

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