Protein Alignment HDAC6 and USP27X

DIOPT Version :9

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001138545.1
• Gene: USP27X / 389856
• HGNCID: 13486
• Length: 438
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 61/338 - (18%)
• Similarity: 92/338 - (27%)
• Gaps: 161/338 - (47%)

  Fly   846 CTKTLLGDPVPT-----PQL------------------GATALQKPPTVAFQSCV---------- 877
            |:...||:..||     |:|                  |...|.......|.:|:
Human    38 CSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPIL 102

  Fly   878 -------------ESLQQCLQVQRNH-WRSLEFVGRRLPRDP-------------VVG--ENNNE 913
                         .|.:.||..:.:. :|.| :.|...|..|             :.|  :.:..
Human   103 RDFFLSDRHRCEMPSPELCLVCEMSSLFREL-YSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAH 166

  Fly   914 DFLTASL--RHLNISNDDATAAA---------------GGLAGD------------RPDCGD--- 946
            :||.|:|  .|.:...||...||               |||..|            ...|.|
Human   167 EFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISL 231

  Fly   947 ERPS----------GSKPKVK-------VKTLSDYLAENKEALEQSEMFAVYPLKTCPHLRLLRP 994
            :.|.          |.:..|.       :.||:|.|.                       |..||
Human   232 DLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLR-----------------------RFTRP 273

  Fly   995 EEAPRSLDSGA--ECSVCGSTGENWVCLSCRH---VACGRYVNAHMEQHSVEEQHPLAMSTADLS 1054
            |.    |.|.|  :|..|.|..|:...|:...   |||..:...   :||.:::..:
Human   274 EH----LGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF---EHSAKQRRKI-------- 323

  Fly  1055 VWCYACSAYVDHP 1067
                  :.|:..|
Human   324 ------TTYISFP 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	15/95 (16%)
		zf-UBP	1007..1069	CDD:280334	12/64 (19%)
USP27X	NP_001138545.1	Peptidase_C19D	78..419	CDD:239125	53/298 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900