DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and HDAC1

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	125/489 - (25%)
Similarity:	207/489 - (42%)	Gaps:	72/489 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 KVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 597
            :|||.||:.:..:  ....|||.:|.||:..|.:..:|||.::|:...|..||.||:...|:..:
  Fly     8 RVCYYYDSDIGNY--YYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEY 70

  Fly   598 VNTVRRLLGREPKELHDAAGIYNSVYLHPRTFD-----CATLAAGLVLQAVDSVLRGESRSGIC- 656
            |..:|.:......|.:.....:|.....| .||     |...|.|.|..||.   ..:..|.||
  Fly    71 VRFLRSIRPDNMSEYNKQMQRFNVGEDCP-VFDGLYEFCQLSAGGSVAAAVK---LNKQASEICI 131

  Fly   657 NVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYI 721
            |.....|||::....|||..|::.:.....::..  :|||.:|.|||||:|.:..|.:..:|:.:
  Fly   132 NWGGGLHHAKKSEASGFCYVNDIVLGILELLKYH--QRVLYIDIDVHHGDGVEEAFYTTDRVMTV 194

  Fly   722 SLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQL 786
            |.|:|  |.:||  ..|:...:|.|.|:.:.||||. :.||.|..|...|..:|..:...|.|..
  Fly   195 SFHKY--GEYFP--GTGDLRDIGAGKGKYYAVNIPL-RDGMDDDAYESIFVPIISKVMETFQPAA 254

  Fly   787 VLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLS------ALASGRIIVCLEGGYNVNSISYAMTM 845
            |::..|.|:..||.||...:|.:|:|....::.      .:..|       |||.:.::|...|.
  Fly   255 VVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGG-------GGYTIRNVSRCWTY 312

  Fly   846 CTKTLLGDPV--------------PTPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEF 896
            .|...|...:              |..:|..:    |..:..|:..|.|:   :::...:.:|..
  Fly   313 ETSVALAVEIANELPYNDYFEYFGPDFKLHIS----PSNMTNQNTSEYLE---KIKNRLFENLRM 370

  Fly   897 VG-------RRLPRDPVVGENNNEDFLTASLR-----------HLNISNDDATAAAGGLAGDRPD 943
            :.       :.:|.|.:..|:::||.:....|           ..|..:|......||...:|..
  Fly   371 LPHAPGVQIQAIPEDAINDESDDEDKVDKDDRLPQSDKDKRIVPENEYSDSEDEGEGGRRDNRSY 435

  Fly   944 CGD-ERPSGSKPKVKVKTLSDYLAENKEALEQSE 976
            .|. :||...|.....|..|:..:|.|:..|:.:
  Fly   436 KGQRKRPRLDKDTNSNKASSETSSEIKDEKEKGD 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	101/382 (26%)
		zf-UBP	1007..1069	CDD:280334
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	105/390 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840