Protein Alignment HDAC6 and Hdac4

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_017452030.3
• Gene: Hdac4 / 363287
• RGDID: 619979
• Length: 1101
• Species: Rattus norvegicus
• Alignment Length: 1075
• Identity: 286/1075 - (26%)
• Similarity: 419/1075 - (38%)
• Gaps: 305/1075 - (28%)

  Fly    99 KSLVRKPTALIYDESMSQHCCLWDKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILR 163
            :.|.|:..|.:::....|...|..|...|..|. .|.|||.|:                :.|:.:
  Rat   111 EQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEH-QRKLERHRQ----------------EQELEK 158

  Fly   164 LHTEEHFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELS---LLASGSTIELVDHLVA---- 221
            .|.|:..::||      :.|:.:|.:.....:.:....|.|:   .||..:    ::|.::
  Rat   159 QHREQKLQQLK------NKEKGKESAVASTEVKMKLQEFVLNKKKALAHRN----LNHCMSSDPR 213

  Fly   222 ---GKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQR 283
               ||.|:.......|....:.|.|      |:..|....|.|...|::..
  Rat   214 YWYGKTQHSSLDQSSPPQSGVSASY------NHPVLGMYDAKDDFPLRKTA-------------- 258

  Fly   284 FFYNDPRVVYFS--IHRFEHGSFWPHLHESD-------------------YHAIGSGAGT----- 322
               ::|.:...|  ..:.......|.|...|                   ..|.|||..:
  Rat   259 ---SEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPSSPNSSS 320

  Fly   323 -------GYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDA------ALGCPE 374
                   |....||......:....|...:..:.|:.|...|.|..::.|..|      |.|..:
  Rat   321 GNVSTENGIAPTVPSTPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQD 385

  Fly   375 GEMEVTPA------CYP--HLL----------------NPLLR----LADARVAVVLEGGYCLDS 411
            .|....||      .:|  ||.                ||||:    |........|...:.|..
  Rat   386 AERLALPALQQRISLFPGTHLTPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTDWYLSG 450

  Fly   412 LAEGA-ALTLRSLLG-DPCPPLV------------ETVPLPRAELAQALLSCIAVHRPHWRCL-- 460
            |  || .|..:||:| |...|.:            ::.|||  :.||| |..:.:.:.|.:.|
  Rat   451 L--GALPLHTQSLVGADRVSPSIHKLRQHRPLGRTQSAPLP--QNAQA-LQHLVIQQQHQQFLEK 510

  Fly   461 -----QLQQTY------------DCVELQDRDKEEDL--HTVLRHWIGGPPPMDRYP-------- 498
                 |.||.:            ...|....:.||:|  |..|.    ..|.:||.|
  Rat   511 HKQQFQQQQLHLSKMISKPSEPPRQPESHPEETEEELREHQALL----DEPYLDRLPGQKEPSLA 571

  Fly   499 ------------------TRDT-----------------AIPLPPEKL--------TSNAARLQV 520
                              ||:.                 |:.|..:::        :..||.:.|
  Rat   572 GVQVKQEPIESEEEEVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPV 636

  Fly   521 --------LRAETK-------LSV------PSFKVCYAYDAQMLLH-CNLNDT-GHPEQPSRIQH 562
                    .||::.       :||      |.|.....||..||.| |...:| .|||...|||.
  Rat   637 SFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQS 701

  Fly   563 IHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREP--------KEL------- 612
            |.....:.||..:.:.:..|.||.:|:...|:.||.    .|.|..|        |:|
  Rat   702 IWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT----LLYGTNPLNRQKLDSKKLLGSLTSV 762

  Fly   613 ----------HDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQ 667
                      .|:..|:|.|:    :...|.||.|.|::.|..|..||.::|...|||||||||:
  Rat   763 FVRLPCGGVGVDSDTIWNEVH----SSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEE 823

  Fly   668 DHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFF 732
            ..|.|||.||:|||||:...:...:.::||||||||||||||..|.::|.|||:|||||:.|:||
  Rat   824 STPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFF 888

  Fly   733 PKGPDGNFDVVGKGAGRGFNVNIPWN---KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFD 794
            |  ..|..|.||.|.|.|||||:.:.   ...|||.||..||:.::||||.||.|.:||||:|||
  Rat   889 P--GSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFD 951

  Fly   795 AAIG--DPLGGCKVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPV-P 856
            |..|  .||||..::|:.:|.||..|..||.|||::.||||:::.:|..|...|...|||:.: |
  Rat   952 AVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELEP 1016

  Fly   857 TPQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVGRRLPRDPVVGENNNEDFLTASLR 921
            .|:   ..|.:.|..   :.|.|:::.:.:...:||.|:    ||  .|.||.:     |..:.:
  Rat  1017 LPE---KVLHQRPNA---NAVHSMEKVMGIHSEYWRCLQ----RL--SPTVGHS-----LIEAQK 1064

  Fly   922 HLNISNDDATAAAGGLAGDRP--DCGDERPSGSKP 954
            ..|...:..||.|....|.:|  ...:|.|...:|
  Rat  1065 CENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEP 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	82/428 (19%)
		HDAC6-dom2	538..895	CDD:212527	156/389 (40%)
		zf-UBP	1007..1069	CDD:460464
Hdac4	XP_017452030.3	None