DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and Hdac10

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_006242280.1	Gene:	Hdac10 / 362981	RGDID:	1305874	Length:	666	Species:	Rattus norvegicus

Alignment Length:	809	Identity:	254/809 - (31%)
Similarity:	376/809 - (46%)	Gaps:	170/809 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 TALIYDESMSQHCCLWDKE--HYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEE 168
            |||:|.|.|:....|||..  ..|||||.|..|:..|:..|.|||..|....|:::|:..:|:.|
  Rat     3 TALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCQCLSVCEASEEELGLVHSPE 67

  Fly   169 HFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRP 233
            :...:::|..: |.|.:..||.:||::|.||.||..:.||:|:.:.|||.::.|...||:|::||
  Rat    68 YIALVQKTQTL-DKEELHTLSKQYDAVYFHPDTFHCARLAAGAALRLVDAVLTGAVHNGVALVRP 131

  Fly   234 PGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHR 298
            ||||:.:|..||:|.|||||:|.:||...:.||||||:|:|||||||.|..|.:||.|:|||.||
  Rat   132 PGHHSQRAAANGFCVFNNVAIAARHAKQKYGLQRILIVDWDVHHGQGIQYIFEDDPSVLYFSWHR 196

  Fly   299 FEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVS 363
            :|||:|||.|.|||...:|.|.|.|:..|:|.|..||.|.||||.|..:|||:|.||.|||::||
  Rat   197 YEHGNFWPFLPESDADTVGRGRGQGFTVNLPWNQVGMGNADYLAAFLHVLLPLAFEFDPELVLVS 261

  Fly   364 AGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPC 428
            ||:|:|:|.|||:|:.||.|:.||...|..||..|:..||||||.|:|||:...:.:::|||||.
  Rat   262 AGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAVLEGGYHLESLAQSVCMMVQTLLGDPT 326

  Fly   429 PPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVELQDRDKEEDLHTVLRHWIGGPPP 493
            ||| ..:.:|.....:::.|......|||..||                :::..||......|
  Rat   327 PPL-PGLMVPCQSALESIQSVRTAQTPHWTSLQ----------------QNVAPVLSSSTHSP-- 372

  Fly   494 MDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVCYAYDAQMLLHCNLNDTGHPEQPS 558
                  ..:::|:..:..|...       ||..||....:.|:                .|..|.
  Rat   373 ------EGSSLPVLADSSTCTV-------AEDSLSPCLDRPCH----------------RPTPPI 408

  Fly   559 RIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNSVY 623
            .|                           .|.||.:.|.::....:|.:|...|.:....:  ..
  Rat   409 CI---------------------------AVALAVSGAALDLPPGVLHQEGSALREETEAW--AR 444

  Fly   624 LHPRTFDCATLAA-GLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAI 687
            ||...|....||| |..|..:|.:|.|:.||                          |||...|:
  Rat   445 LHKSQFQDDDLAALGKSLCLLDGILDGQIRS--------------------------AIATTTAL 483

  Fly   688 RDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKG-----A 747
            .......|||.....|.|.          ::|.::|.:.          |...|:.|.|     :
  Rat   484 ATAATLGVLIQRCVAHRGQ----------RLLCVALGQL----------DRPLDLAGNGRILWLS 528

  Fly   748 GRG--------FNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGC 804
            .||        |:.:.|..:...|.|.:.|.   |::|:||.|.|.:||::.|       |..|.
  Rat   529 IRGKEADIWSMFHFSTPLPQTTGGFLSFILG---LVLPLAYGFQPDMVLMALG-------PAHGL 583

  Fly   805 KVTAEGYGMLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPP 869
            : .|:. .:|...|.:...|||:..:|   ..:.:..|.|: .:.|.|:  ..|.||..::..|
  Rat   584 Q-NAQA-ALLAAMLRSPVGGRILALVE---EESILQLARTL-AQVLHGE--TPPSLGPFSMASP- 639

  Fly   870 TVAFQSCVESLQQCLQVQRN---HWRSLE 895
                    |.:|..:.::..   .|:.|:
  Rat   640 --------EEIQALMFLKAQLEPRWKLLQ 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	159/339 (47%)
		HDAC6-dom2	538..895	CDD:212527	74/373 (20%)
		zf-UBP	1007..1069	CDD:280334
Hdac10	XP_006242280.1	Arginase_HDAC	18..354	CDD:302587	158/337 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1403
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920