DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and Usp44

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001193780.1	Gene:	Usp44 / 327799	MGIID:	3045318	Length:	711	Species:	Mus musculus

Alignment Length:	104	Identity:	36/104 - (34%)
Similarity:	51/104 - (49%)	Gaps:	8/104 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   986 CPHLRLLRPEEAPRSLDSGA-ECSVCGSTGENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMS 1049
            |.|:..|:..:....||... .|.||.:|...|.||||.|||||:|:..|..:|..|..||:|..
Mouse     4 CKHVEQLQLAQGHSILDPQKWYCMVCNTTESIWACLSCSHVACGKYIQEHALKHFQESSHPVAFE 68

  Fly  1050 TADLSVWCYACSAYV-------DHPRLYAYLNPLHEDKF 1081
            ..|:..:||.|:.||       |...|.:.|:.:...|:
Mouse    69 VNDMYAFCYLCNDYVLNDNAAGDLKSLRSTLSTIKSKKY 107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527
		zf-UBP	1007..1069	CDD:280334	28/68 (41%)
Usp44	NP_001193780.1	zf-UBP	26..88	CDD:366940	27/61 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..251
		UCH	272..674	CDD:366104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910