Protein Alignment HDAC6 and hdac10

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_073797913.1
• Gene: hdac10 / 327253
• ZFINID: ZDB-GENE-030131-5464
• Length: 689
• Species: Danio rerio
• Alignment Length: 823
• Identity: 261/823 - (31%)
• Similarity: 377/823 - (45%)
• Gaps: 208/823 - (25%)

  Fly   106 TALIYDESMSQHCCLWDKE--HYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEE 168
            :|||:||.||::..||...  ..|.|||.|...|..|...|.:||..:|.|.||:.|||..|:||
Zfish    18 SALIFDEEMSRYKLLWTDPACEIEVPERLTVSYEALRTHGLAQRCKAVPVRQATEQEILLAHSEE 82

  Fly   169 HFERLKETSGIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRP 233
            :.|.:|:|.|:..:|.| ..|.:|:.:|.|.:.:..:.||:|:|::|||.::..:.:||||::||
Zfish    83 YLEAVKQTPGMNVEELM-AFSKKYNDVYFHQNIYHCAKLAAGATLQLVDSVMKREVRNGMALVRP 146

  Fly   234 PGHHAMKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHR 298
            ||||:.::..||:|.|||||:|..:|...:.|.||||:|:|||||||.|..|..||.|:|||.||
Zfish   147 PGHHSQRSAANGFCVFNNVAIAALYAKKNYNLNRILIVDWDVHHGQGIQYCFEEDPSVLYFSWHR 211

  Fly   299 FEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVS 363
            :||.||||:|.||||.::|.|.|:|:|.|:|.|..||||.||||.|..:|||||.||.|||:|||
Zfish   212 YEHQSFWPNLPESDYSSVGKGKGSGFNINLPWNKVGMTNSDYLAAFFHVLLPVAYEFDPELVIVS 276

  Fly   364 AGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPC 428
            ||:|:|:|.|||||...|..:.||.:.|:.||..::.|||||||.|.||.:....|:.||||||.
Zfish   277 AGFDSAIGDPEGEMCALPEIFAHLTHLLMPLAAGKMCVVLEGGYNLTSLGQSVCQTVHSLLGDPT 341

  Fly   429 PPLVETVPLPRAELAQALLSCIA-------VHRPHWRCLQ-LQQTYDCVELQDRDKEEDLHTVLR 485
            |.:        :.|..|..|.:.       |...:|...: |.|:      :...|...|....|
Zfish   342 PRI--------SGLGTACDSALESIQNVRNVQSSYWSGFKHLAQS------ETNPKRPRLDATNR 392

  Fly   486 HWIGGP-----PPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAE---TKLSVPSFKVC-YAYDAQ 541
                ||     |..:..|.:.....:.||.|....|.::.:.|.   .:|::|  |.| ::.|..
Zfish   393 ----GPKESSEPASESNPKKTAQDIVWPEPLKRTPASVRTVVAPPPGVELTLP--KNCQHSGDVS 451

  Fly   542 MLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLG 606
                   ..|....|..|.:|.|.:.|.                             |.:|.|
Zfish   452 -------ESTAKEVQRIRDKHFHDLTDQ-----------------------------NILRSL-- 478

  Fly   607 REPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPH 671
                                          |.::..:|.::|.:.   :||
Zfish   479 ------------------------------GNIISVLDRMMRSDE---VCN-------------- 496

  Fly   672 GFCIFNNVAIAAQYAIRDF---GLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFP 733
            |..:.::::::.|.|::..   ..||||:|                     |:.
Zfish   497 GCVVVSDLSVSVQCALQHALTEPAERVLVV---------------------YVG----------- 529

  Fly   734 KGPDGNFDVVGKGAGRGFNVNI---PWNKKGMGDLEYAL--------AFQQ----LIMPIAYEFN 783
               ||.|. |....|:.|.|.|   ....|.:..|...|        .|.|    ||:|:|||||
Zfish   530 ---DGEFP-VKTNDGKVFLVQICTKETEDKCVNRLSLCLREGESLTAGFMQALLGLILPVAYEFN 590

  Fly   784 PQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHW------LSALASGRIIVCLEGGYNVNSISYA 842
            |.|||      ..:|:       ||...|::|.|      :..||.||.:..|: ||:.:    .
Zfish   591 PALVL------GIVGE-------TAAKTGLMTVWGHMTCLIQGLAKGRTLTLLQ-GYDKD----L 637

  Fly   843 MTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCLQ 885
            :.:....|.|..: :| ||.....||..|   ..:|..:|.||
Zfish   638 LELTVSALSGASI-SP-LGPLRALKPEDV---EMMEKQRQRLQ 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	161/346 (47%)
		HDAC6-dom2	538..895	CDD:212527	74/372 (20%)
		zf-UBP	1007..1069	CDD:460464
hdac10	XP_073797913.1	None