DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC6 and hdac10

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:XP_021326130.1 Gene:hdac10 / 327253 ZFINID:ZDB-GENE-030131-5464 Length:723 Species:Danio rerio


Alignment Length:868 Identity:266/868 - (30%)
Similarity:392/868 - (45%) Gaps:213/868 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 KRRARNNMLKNQGC--GSQESVTD---------IFQNAVNSKSLVRKPTALIYDESMSQHCCLWD 122
            |||.|....|:...  .|..|||.         :|.........:...:|||:||.||::..||.
Zfish     5 KRRKRTKKKKHDTFEPASFASVTKYILQVLLCCLFHRRQTKSVKMASGSALIFDEEMSRYKLLWT 69

  Fly   123 KE--HYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETSGIRDDERM 185
            ..  ..|.|||.|...|..|...|.:||..:|.|.||:.|||..|:||:.|.:|:|.|:..:|.|
Zfish    70 DPACEIEVPERLTVSYEALRTHGLAQRCKAVPVRQATEQEILLAHSEEYLEAVKQTPGMNVEELM 134

  Fly   186 EELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFN 250
             ..|.:|:.:|.|.:.:..:.||:|:|::|||.::..:.:||||::||||||:.::..||:|.||
Zfish   135 -AFSKKYNDVYFHQNIYHCAKLAAGATLQLVDSVMKREVRNGMALVRPPGHHSQRSAANGFCVFN 198

  Fly   251 NVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHA 315
            |||:|..:|...:.|.||||:|:|||||||.|..|..||.|:|||.||:||.||||:|.||||.:
Zfish   199 NVAIAALYAKKNYNLNRILIVDWDVHHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSS 263

  Fly   316 IGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVT 380
            :|.|.|:|:|.|:|.|..||||.||||.|..:|||||.||.|||:|||||:|:|:|.|||||...
Zfish   264 VGKGKGSGFNINLPWNKVGMTNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCAL 328

  Fly   381 PACYPHLLNPLLRLADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQA 445
            |..:.||.:.|:.||..::.|||||||.|.||.:....|:.||||||.|.:        :.|..|
Zfish   329 PEIFAHLTHLLMPLAAGKMCVVLEGGYNLTSLGQSVCQTVHSLLGDPTPRI--------SGLGTA 385

  Fly   446 LLSCIA-------VHRPHWRCLQ-LQQTYDCVELQDRDKEEDLHTVLRHWIGGP-----PPMDRY 497
            ..|.:.       |...:|...: |.|:      :...|...|...    .|||     |..:..
Zfish   386 CDSALESIQNVRNVQSSYWSSFKHLAQS------ETNPKRPRLDAT----NGGPKESSEPASESN 440

  Fly   498 P---TRDTAIPLPPEKLTSNAARLQVLRAETKLSVPSFKVC-YAYDAQMLLHCNLNDTGHPEQPS 558
            |   .:|...|.|.:::.::...:.|.....:|::|  |.| ::.|..       ..|....|..
Zfish   441 PKKTAQDIVWPEPLKRMPASVRTVVVPPPGVELTLP--KNCQHSGDIS-------ESTAKEVQRI 496

  Fly   559 RIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAHVNTVRRLLGREPKELHDAAGIYNSVY 623
            |.:|.|.:.|.                             |.:|.|                   
Zfish   497 RDKHFHDLTDQ-----------------------------NILRSL------------------- 513

  Fly   624 LHPRTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIR 688
                         |.::..:|.::|.:.   :||              |..:.::::::.|.|::
Zfish   514 -------------GNIISVLDRMMRSDE---VCN--------------GCVVVSDLSVSVQCALQ 548

  Fly   689 DF---GLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRG 750
            ..   ..||||:    |:.|:|...:..::.||..:.:...|                       
Zfish   549 HALTEPAERVLV----VYVGDGELPVKTNDGKVFLVQICTKE----------------------- 586

  Fly   751 FNVNIPWNKKGMGDLEYAL--------AFQQ----LIMPIAYEFNPQLVLVSAGFDAAIGDPLGG 803
                  ...|.:..|...|        .|.|    ||:|:||||||.|||      ..:|:    
Zfish   587 ------TEDKCVNRLSLCLREGESLTAGFMQALLGLILPVAYEFNPALVL------GIVGE---- 635

  Fly   804 CKVTAEGYGMLTHW------LSALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGA 862
               ||...|::|.|      :..||.||.:..|: ||:.:    .:.:....|.|..: :| ||.
Zfish   636 ---TAAKTGLMTVWGHMTCLIQGLARGRTLTLLQ-GYDKD----LLELTVSALSGASI-SP-LGP 690

  Fly   863 TALQKPPTVAFQSCVESLQQCLQ 885
            ....||..|   ..:|..:|.||
Zfish   691 LRALKPEDV---EMMEKQRQRLQ 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526 161/346 (47%)
HDAC6-dom2 538..895 CDD:212527 70/369 (19%)
zf-UBP 1007..1069 CDD:280334
hdac10XP_021326130.1 HDAC10 68..404 CDD:212546 160/344 (47%)
Arginase_HDAC <607..717 CDD:327367 39/127 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 324 1.000 Domainoid score I1175
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 1 1.000 - - FOG0001161
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48252
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2991
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
98.910

Return to query results.
Submit another query.