DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC6 and HDAC2

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:NP_001518.3 Gene:HDAC2 / 3066 HGNCID:4853 Length:488 Species:Homo sapiens


Alignment Length:478 Identity:115/478 - (24%)
Similarity:198/478 - (41%) Gaps:64/478 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   533 KVCYAYDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 597
            ||||.||..:..:  ....|||.:|.||:..|.:..:|||.::|:...|..||.:|:...|:..:
Human    11 KVCYYYDGDIGNY--YYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEY 73

  Fly   598 VNTVRRLLGREPKELHDAAGIYNSVYLHPRTFD-----CATLAAGLVLQAVDSVLRGESRSGICN 657
            :..:|.:......|.......:|.....| .||     |.....|.|..||.  |..:......|
Human    74 IKFLRSIRPDNMSEYSKQMQRFNVGEDCP-VFDGLFEFCQLSTGGSVAGAVK--LNRQQTDMAVN 135

  Fly   658 VRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYIS 722
            .....|||::....|||..|::.:|....::..  :|||.:|.|:|||:|.:..|.:..:|:.:|
Human   136 WAGGLHHAKKSEASGFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVS 198

  Fly   723 LHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLV 787
            .|:|  |.:||  ..|:...:|.|.|:.:.||.|. :.|:.|..|...|:.:|..:...:.|..|
Human   199 FHKY--GEYFP--GTGDLRDIGAGKGKYYAVNFPM-RDGIDDESYGQIFKPIISKVMEMYQPSAV 258

  Fly   788 LVSAGFDAAIGDPLGGCKVTAEGYG-----MLTHWLSALASGRIIVCLEGGYNVNSISYAMTMCT 847
            ::..|.|:..||.||...:|.:|:.     :.|..|..|..|      .|||.:.:::...|..|
Human   259 VLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG------GGGYTIRNVARCWTYET 317

  Fly   848 KTLLGDPVPT------------PQLGATALQKPPTVAFQSCVESLQQCLQVQRNHWRSLEFVG-- 898
            ...|...:|.            |......  .|..:..|:..|.:::..|....:.|.|....  
Human   318 AVALDCEIPNELPYNDYFEYFGPDFKLHI--SPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGV 380

  Fly   899 --RRLPRDPVVGENNNED--------FLTASLRHLNISNDDATAAAGGLAGDRPDCGDERPSGSK 953
              :.:|.|.|..::.:||        .:.||.:.:....:.:.:...| .|.|.:..|.:....|
Human   381 QMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEG-EGGRRNVADHKKGAKK 444

  Fly   954 PKVKVKTLSDYLAENKEALEQSE 976
            .:::         |:|:..|..:
Human   445 ARIE---------EDKKETEDKK 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526
HDAC6-dom2 538..895 CDD:212527 95/378 (25%)
zf-UBP 1007..1069 CDD:280334
HDAC2NP_001518.3 HDAC2 9..374 CDD:212535 99/382 (26%)
Histone deacetylase 9..322 91/328 (28%)
CobT2 <386..>479 CDD:226920 15/83 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..488 13/80 (16%)
RPN2_C <436..>488 CDD:375480 5/32 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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