DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC6 and Usp30

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001100623.1	Gene:	Usp30 / 304579	RGDID:	1307949	Length:	517	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	59/310 - (19%)
Similarity:	98/310 - (31%)	Gaps:	121/310 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 GGYC-LDSLAEGAALTLRSLLGDPCPPLVE-----TVPLPRAELAQALLSCIAVHRPHWRCLQLQ 463
            |..| ::||.:|.:         .||..|:     |....|.:.......|:::     ..|.|.
  Rat    74 GNTCFMNSLLQGLS---------ACPAFVKWLEEFTTQYSRDQQGPHTHQCLSL-----TLLSLL 124

  Fly   464 QTYDCVELQDRDKEEDLHTVLRHWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETKLS 528
            :...|.|:.:                                   |::...:..|.|||. .:..
  Rat   125 KALSCQEVTE-----------------------------------EEVLDASCLLDVLRM-YRWQ 153

  Fly   529 VPSFKVCYAYDAQMLLH---CNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVC 590
            :.||:   ..||..|.|   .:|.|. ...|| |:.|:..:|.    |:|..:::||..|
  Rat   154 ISSFE---EQDAHELFHVITSSLEDE-RDRQP-RVTHLFDVHS----LEQQSEMAPRQVT----- 204

  Fly   591 LAHTRAHVNTVRRLLGREPKELHDAAGIYNSVY-LHPRTFDCATLAAGLVLQAVDSVLRGESRSG 654
             .|||.           .|   |.....:.|.: .|.|.                      |.:.
  Rat   205 -CHTRG-----------SP---HPTTNPWKSQHPFHGRL----------------------SSNM 232

  Fly   655 ICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHH 704
            :|.      |.|...|..|..|::::::...|  .:|  ..|.:|..:||
  Rat   233 VCK------HCEHQSPVRFDTFDSLSLSIPAA--TWG--HPLTLDHCLHH 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	11/57 (19%)
		HDAC6-dom2	538..895	CDD:212527	37/171 (22%)
		zf-UBP	1007..1069	CDD:280334
Usp30	NP_001100623.1	Peptidase_C19F	69..500	CDD:239127	59/310 (19%)
		UBP12	<69..>265	CDD:227847	55/301 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900