DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC6 and clr3

DIOPT Version :9

Sequence 1:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_595104.1	Gene:	clr3 / 2540821	PomBaseID:	SPBC800.03	Length:	687	Species:	Schizosaccharomyces pombe

Alignment Length:	574	Identity:	176/574 - (30%)
Similarity:	280/574 - (48%)	Gaps:	79/574 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ATAAGGTGSSSGSISGGFNAADP----RKSNKPNAALLEAKRRARNNMLKNQGCGSQESVTDIFQ 93
            |:.:.|..:|........|...|    ..:|||.:                   ||:.::    .
pombe     3 ASNSDGASTSVKPSDDAVNTVTPWSILLTNNKPMS-------------------GSENTL----N 44

  Fly    94 NAVNSKSLVRKPTALIYDESMSQHCCLWD-KEHYECPERFTRVLERCRELNLTERC-------LE 150
            |..:..|.:.|.:.|.||..|..|..|.: .:|.|.|.|..||.|..::.......       |.
pombe    45 NESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLR 109

  Fly   151 LPSRSATKDEILRLHTEEHFERLKETSGIRDDE--RMEELSSRYDSIYIHPSTFELSLLASGSTI 213
            :|:|.||.:|:|::|::|.::|:..|..:..::  .:|::|   ||:|.:..:...:.||.||.|
pombe   110 IPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS---DSLYYNNESAFCARLACGSAI 171

  Fly   214 ELVDHLVAGKAQNGMAIIRPPGHHAMKAEYNGYCFFNNVALATQHALD--VHKLQRILIIDYDVH 276
            |....:|.|:.:|..|::|||||||...:..|:|.||||::..:..|.  ..|::|:||:|:|:|
pombe   172 ETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIH 236

  Fly   277 HGQGTQRFFYNDPRVVYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYL 341
            ||.|||..||:||.|:|.|:||:|:|.|:|..:.......|.|.|.|...|:|.:..||.:|||:
pombe   237 HGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYI 301

  Fly   342 AIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGG 406
            ..||::::|||.||.|:|:|||.|:|||.|...|:..:|||.|.|:...|:.|||.:|.:.||||
pombe   302 YAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGG 366

  Fly   407 YCLDSLAEGAALTLRSLLGDPCPPLVETVPLPRAELAQALLSCIAVHRPHWRCLQLQQTYDCVEL 471
            |.|||::..|....:||||.|...|..|...|:|  ...:.....:...:|||::.:.    .:.
pombe   367 YNLDSISTSALAVAQSLLGIPPGRLHTTYACPQA--VATINHVTKIQSQYWRCMRPKH----FDA 425

  Fly   472 QDRDKEED-LHTVLR---------HWIGGPPPMDRYPTRDTAIPLPPEKLTSNAARLQVLRAETK 526
            ..:|...| ||.|:|         .|            :.|.:|:..:.: ||....|||.:...
pombe   426 NPKDAHVDRLHDVIRTYQAKKLFEDW------------KITNMPILRDSV-SNVFNNQVLCSSNF 477

  Fly   527 LSVPSFKVCYAYDAQMLLH-------CNLNDTGHPEQPSRIQHIHKMHDDYGLL 573
            ....:..|......::|.:       .||||:...: |..:.....|..|:||:
pombe   478 FQKDNLLVIVHESPRVLGNGTSETNVLNLNDSLLVD-PVSLYVEWAMQQDWGLI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	130/349 (37%)
		HDAC6-dom2	538..895	CDD:212527	10/43 (23%)
		zf-UBP	1007..1069	CDD:280334
clr3	NP_595104.1	HDAC_Clr3	75..392	CDD:212542	125/319 (39%)
clr3	NP_595104.1	Arb2	398..562	CDD:286800	30/153 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	245	1.000	Domainoid score	I421
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001161
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X2174
TreeFam	1	0.960	-	-
	9	8.800