DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC6 and Hdac11

DIOPT Version :9

Sequence 1:NP_001259569.1 Gene:HDAC6 / 32461 FlyBaseID:FBgn0026428 Length:1179 Species:Drosophila melanogaster
Sequence 2:NP_659168.1 Gene:Hdac11 / 232232 MGIID:2385252 Length:347 Species:Mus musculus


Alignment Length:269 Identity:71/269 - (26%)
Similarity:113/269 - (42%) Gaps:43/269 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   563 IHKMHD-DYG-------LLKQMKQLS------PRAATTDEVCLAHTRAHVNTVR-----RLLGRE 608
            :.|:|. |.|       .||:.|.||      .|.|:.:::.:.|||.::|.::     ..:...
Mouse    31 LEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEI 95

  Fly   609 PKELHDAAGIYNSVYLHP-RTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHG 672
            |..:.....:.....|.| ||....|:.||.:  ||:       |....||....||...|...|
Mouse    96 PPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKL--AVE-------RGWAINVGGGFHHCSSDRGGG 151

  Fly   673 FCIFNNVAIAAQYAI-RDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGP 736
            ||.:.::.:|.::.. |..|:.|..|:|.|.|.|||.:..|..:.:|..:.::. .|  .:|.  
Mouse   152 FCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYN-RH--IYPG-- 211

  Fly   737 DGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPL 801
                |...|.|.|. .|.:.|   |..|.||....::.:.....|..|.:|:.:||.|...||.|
Mouse   212 ----DRFAKEAIRR-KVELEW---GTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRL 268

  Fly   802 GGCKVTAEG 810
            ||..::..|
Mouse   269 GGLSISPAG 277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6NP_001259569.1 HDAC10_HDAC6-dom1 119..457 CDD:212526
HDAC6-dom2 538..895 CDD:212527 71/269 (26%)
zf-UBP 1007..1069 CDD:280334
Hdac11NP_659168.1 Histone deacetylase 14..318 71/269 (26%)
HDAC_classIV 35..319 CDD:212519 70/265 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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