Protein Alignment HDAC6 and Hdac11

DIOPT Version :10

• Sequence 1: NP_001259569.1
• Gene: HDAC6 / 32461
• FlyBaseID: FBgn0026428
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_659168.1
• Gene: Hdac11 / 232232
• MGIID: 2385252
• Length: 347
• Species: Mus musculus
• Alignment Length: 269
• Identity: 71/269 - (26%)
• Similarity: 113/269 - (42%)
• Gaps: 43/269 - (15%)

  Fly   563 IHKMHD-DYG-------LLKQMKQLS------PRAATTDEVCLAHTRAHVNTVR-----RLLGRE 608
            :.|:|. |.|       .||:.|.||      .|.|:.:::.:.|||.::|.::     ..:...
Mouse    31 LEKLHPFDAGKWGKVINFLKEEKLLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEI 95

  Fly   609 PKELHDAAGIYNSVYLHP-RTFDCATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHG 672
            |..:.....:.....|.| ||....|:.||.:  ||:       |....||....||...|...|
Mouse    96 PPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKL--AVE-------RGWAINVGGGFHHCSSDRGGG 151

  Fly   673 FCIFNNVAIAAQYAI-RDFGLERVLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGP 736
            ||.:.::.:|.::.. |..|:.|..|:|.|.|.|||.:..|..:.:|..:.::. .|  .:|.
Mouse   152 FCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYN-RH--IYPG-- 211

  Fly   737 DGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGDPL 801
                |...|.|.|. .|.:.|   |..|.||....::.:.....|..|.:|:.:||.|...||.|
Mouse   212 ----DRFAKEAIRR-KVELEW---GTEDEEYLEKVERNVRRSLQEHLPDVVVYNAGTDVLEGDRL 268

  Fly   802 GGCKVTAEG 810
            ||..::..|
Mouse   269 GGLSISPAG 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527	71/269 (26%)
		zf-UBP	1007..1069	CDD:460464
Hdac11	NP_659168.1	Histone deacetylase	14..318		71/269 (26%)
		HDAC_classIV	35..319	CDD:212519	70/265 (26%)